144457-43-2

Basic information

• Product Name: Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester
• Synonyms: Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester;Methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)acetate;Thieno[2,3-c]pyridine-6(5H)-acetic acid,a-(2-chlorophenyl)-4,7-dihydro-, Methyl ester, hydrochloride;Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, Methyl este;Clopidogrel Related Compound B (sulfate);Methyl 2-(7-(2-chlorophenyl)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)acetate;methyl2-(2-chlorophenyl)-2-(5,7-dihydro-4H-thieno[2,3-c]pyridin-6-yl)acetate
• CAS NO: 144457-43-2
• Molecular Formula: C₁₆H₁₆ClNO₂S
• Molecular Weight: 322
• Mol File: 144457-43-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 423.7 °C at 760 mmHg
• Flash Point: 210 °C
• Appearance: /
• Density: 1.317 g/cm³
• Vapor Pressure: 2.19E-07mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester(144457-43-2)
• EPA Substance Registry System: Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester(144457-43-2)

Safety Data

• Hazardous Substances Data: 144457-43-2(Hazardous Substances Data)

Usage

Uses

Methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7h)-yl)acetate

InChI:InChI=1/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-11-7-9-21-14(11)10-18/h2-5,7,9,15H,6,8,10H2,1H3

Upstream product

• 114896-65-0 3-(2'-iodoethyl) thiophene 
• 141109-14-0 2-(2-chlorophenyl)glycine methyl ester hydrochloride 
• 62019-71-0 4,5,6,7-tetrahydro-thieno[2,3-c]pyridine 
• 85259-19-4 methyl 2-bromo-2-(2-chlorophenyl)acetate 
• 50-00-0 formaldehyd 
• 1427465-90-4 methyl 2-(2-(thiophen-3-yl)ethylamino)-2-(2-chlorophenyl)acetate 
• 29270-30-2 α-bromo-2-chlorophenyl acetic acid 
• 59311-67-0 2-(3-thienyl)ethylamine 

Downstream Products

• 1396841-05-6 methyl (S)-(+)-2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)acetate 
• 144750-52-7 methyl 2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridine-6(7H)-yl)acetate hydrochloride 
• 1396607-35-4 methyl (S)-(+)-2-(2-chlorophenyl)-2-(4,5-dihydrothieno[2,3-c]pyridine-6(7H)-yl)acetate hydrochloride 

Relevant articles and documents

Synthesis and characterization of impurity B of S-(+)-clopidogrel bisulfate: An antiplatelet

S-(+)-Clopidogrel bisulfate [(S-(+)-methyl 2-(2-chlorophenyl)-2-(6, 7-dihydrothieno[3, 2-c]pyridin-5(4H)-yl)acetate bisulfate)] is a platelet aggregation inhibitor drug. S-(+)-Clopidogrel bisulfate is prepared by different synthetic approaches in the literature. In almost all the approaches the major impurities known in the literature (A, B, and C) are also listed in the U.S. pharmacopoeia. The control of these pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. In this article, a description of these impurities and their origins in the S-(+)-clopidogrel bisulfate process are presented along with the preparation of impurity B.