1446518-79-1

Basic information

• Product Name: 2-iso-butyryl-2-(3-(4-nitrophenoxy)prop-1-en-2-yl)cyclohexanone
• Synonyms: 2-iso-butyryl-2-(3-(4-nitrophenoxy)prop-1-en-2-yl)cyclohexanone
• CAS NO: 1446518-79-1
• Molecular Weight: 345.395
• Mol File: 1446518-79-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-iso-butyryl-2-(3-(4-nitrophenoxy)prop-1-en-2-yl)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iso-butyryl-2-(3-(4-nitrophenoxy)prop-1-en-2-yl)cyclohexanone(1446518-79-1)
• EPA Substance Registry System: 2-iso-butyryl-2-(3-(4-nitrophenoxy)prop-1-en-2-yl)cyclohexanone(1446518-79-1)

Safety Data

• Hazardous Substances Data: 1446518-79-1(Hazardous Substances Data)

Upstream product

• 39207-65-3 2-(2-methyl-1-oxopropane)cyclohexanone 
• 100-02-7 4-nitro-phenol 
• 1446518-30-4 2-iso-butyrylcyclohex-1-enyl prop-2-ynyl carbonate 

Relevant articles and documents

Palladium-Catalysed Construction of All-Carbon Quaternary Centres with Propargylic Electrophiles: Challenges in the Simultaneous Control of Regio-, Chemo- and Enantioselectivity

This article describes the palladium-catalysed three-component coupling of 1,3-dicarbonyl compounds with nucleophiles and propargylic electrophiles for the generation of quaternary all-carbon centres in a single step, which necessitates the simultaneous control of regio-, chemo- and enantioselectivity. The use of propargyl enol carbonates, the source of two of the components, was found to be essential in maintaining high levels of regiocontrol and chemoselectivity, whereas a careful analysis of p K a trends of O-, C- and N-nucleophiles as the other coupling partner indicates that the highest levels of selectivity are likely to be obtained with relatively acidic species, such as phenols, 1,3-dicarbonyl compounds and aromatic N-heterocycles. Finally, studies towards the development of the catalytic enantioselective construction of quaternary all-carbon centres by means of alkenylation and allylic alkylation are disclosed.