1452-16-0Relevant articles and documents
Preparation method of medicinal intermediate 2-cyanothiazole
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Paragraph 0017-0024, (2019/03/08)
The invention provides a preparation method of medicinal intermediate 2-cyanothiazole. The preparation method comprises the steps that in a reaction container, N-methylimidazole serves as a reaction solvent, CuI serves as a catalyst, K4[Fe(CN)6] and 2-bro
Synthesis of nitriles from aldehydes with trimethylphenylammonium tribromide and ammonium acetate
Sayama, Shinsei
, p. 1796 - 1802 (2016/11/06)
Various aromatic and heterocyclic aldehydes were easily converted to respective nitriles with the combination of trimethylphenylammonium tribromide and ammonium acetate in good yields at room temperature.
Schmidt reaction in ionic liquids: Highly efficient and selective conversion of aromatic and heteroaromatic aldehydes to nitriles with [BMIM(SO3H)][OTf] as catalyst and [BMIM][PF6] as solvent
Nandi, Ganesh C.,Laali, Kenneth K.
, p. 2177 - 2179 (2013/04/24)
A mild and selective method is presented for the conversion of aromatic and heteroaromatic aldehydes to nitriles via the Schmidt reaction with TMSN 3 by using [BMIM(SO3H)][OTf] as catalyst and [BMIM][PF6] as solvent. The method offers high yields and simple product isolation, and avoids the use of liquid superacids or corrosive Lewis acids commonly employed for this transformation. It also offers some potential for recycling/reuse of the IL solvent.