438545-36-9

Basic information

• Product Name: 2-(1H-IMIDAZOL-2-YL)-THIAZOLE
• Synonyms: 2-(1H-IMIDAZOL-2-YL)-THIAZOLE;2-(1H-IMIDAZOL-2-YL)-1,3-THIAZOLE;2-(1H-2-Imidazolyl)thiazole
• CAS NO: 438545-36-9
• Molecular Formula: C₆H₅N₃S
• Molecular Weight: 151.189
• Mol File: 438545-36-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 374.177°C at 760 mmHg
• Flash Point: 188.408°C
• Appearance: /
• Density: 1.387g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(1H-IMIDAZOL-2-YL)-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-IMIDAZOL-2-YL)-THIAZOLE(438545-36-9)
• EPA Substance Registry System: 2-(1H-IMIDAZOL-2-YL)-THIAZOLE(438545-36-9)

Safety Data

• Hazardous Substances Data: 438545-36-9(Hazardous Substances Data)

Usage

General Description

2-(1H-Imidazol-2-yl)-thiazole is a chemical compound with the molecular formula C6H5N3S. It is a heterocyclic compound that contains both imidazole and thiazole rings. 2-(1H-IMIDAZOL-2-YL)-THIAZOLE is often used as a building block in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and the presence of potentially bioactive functional groups. It also exhibits antifungal and antibacterial properties, making it a potentially valuable compound in the development of new drugs. The imidazole and thiazole rings in the structure also make it an attractive target for medicinal chemistry research, as compounds containing these motifs have been shown to exhibit wide-ranging pharmacological activity.

InChI:InChI=1/C6H5N3S/c1-2-8-5(7-1)6-9-3-4-10-6/h1-4H,(H,7,8)

Upstream product

• 438554-20-2 2-(1-ethoxymethyl-1H-imidazol-2-yl)-thiazole 
• 1452-16-0 thiazole-2-carbonitrile 
• 22483-09-6 2,2-dimethoxyethylamine 

Downstream Products

• 627910-68-3 3-methoxy-5-phenyl-2-(2-thiazol-2-yl-imidazol-1-ylmethyl)-pyrazine 

Relevant articles and documents

PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE

The present invention provides compounds having a structure according to Formula (I) or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

Substituted ring-fused imidazole derivative: GABAA receptors ligands

Substituted ring-fused imidazole derivatives that bind to GABAA receptors are provided. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a v

Benzimidazole and pyridylimidazole derivatives

This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.