145625-14-5

Basic information

• Product Name: Carbamic acid, [(1S)-1-[(hydroxyimino)methyl]-2-phenylethyl]-, 1,1-dimethylethyl ester
• CAS NO: 145625-14-5
• Molecular Formula: C14H20N2O3
• Molecular Weight: 264.324
• Mol File: 145625-14-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-[(hydroxyimino)methyl]-2-phenylethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-[(hydroxyimino)methyl]-2-phenylethyl]-, 1,1-dimethylethyl ester(145625-14-5)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-[(hydroxyimino)methyl]-2-phenylethyl]-, 1,1-dimethylethyl ester(145625-14-5)

Safety Data

• Hazardous Substances Data: 145625-14-5(Hazardous Substances Data)

Upstream product

• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 63-91-2 L-phenylalanine 
• 251325-80-1 [1-(hydroxyimino-methyl)-2-phenyl-vinyl]-carbamic acid tert-butyl ester 
• 72155-45-4 Boc-L-phenylalaninal 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 

Downstream Products

• 145625-20-3 3-<(1S)-N-(tert-butyloxycarbonyl)amino-2-phenylethyl>-5-<(2R)-(bornane-10,2-sultamyl)-N-carbonyl>-(5R)-Δ²-isoxazoline 
• 175777-70-5 {(S)-1-[(S)-5-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-4,5-dihydro-isoxazol-3-yl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 99281-90-0 (S)-2-(tert-butoxycarbonylamino)-3-phenylpropanenitrile 
• 1311399-84-4 C₁₇H₂₀N₂O₅ 
• 159598-13-7 C₁₄H₁₈N₂O₃ 
• 162148-08-5 (S)-3-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-4,5-dihydro-isoxazole-5-carboxylic acid 
• 154509-90-7 (1'S,5S)-3-<1-N-(tert-butyloxycarbonyl)amino-2-phenylethyl>-5-methoxycarbonyl-Δ²-isoxazoline 
• 145625-25-8 (1'S,5R)-3-<1-N-(tert-butyloxycarbonyl)amino-2-phenylethyl>-5-methoxycarbonyl-Δ²-isoxazoline 
• 162148-02-9 (R)-3-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-4,5-dihydro-isoxazole-5-carboxylic acid 
• 847357-59-9 [1-(N-allyl-N-benzyl-N'-hydroxy-carbamimidoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 847357-65-7 [1-(1-benzyl-4-methyl-1H-imidazol-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 449152-87-8 {1-[5-(3-benzoyl-5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-isoxazol-3-yl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 159598-23-9 C₁₄H₁₉ClN₂O₃ 
• 146552-72-9 (S)-2-(t-butoxycarbonylamino)-3-phenylpropylamine 

Relevant articles and documents

METHOD FOR PRODUCING CHIRAL AMINONITRILES

The invention relates to a method for preparing an N-acyl- or N-sulfonyl-α-aminonitrile, comprising the following steps: a) condensation of an N-acyl- or N-sulfonyl-α-aminoaldehyde with hydroxylamine to give an aldoxime, and b) dehydration of the aldoxime

One-pot conversion of aldehydes to nitriles mediated by TiCl4

A simple and convenient one-pot synthesis of nitriles from the corresponding aliphatic and aromatic aldehydes has been developed. The titanium tetrachloride assisted reaction was conducted in pyridine under mild conditions using various types of aldehyde precursors and gave the corresponding nitriles in excellent yields. The application of the adopted protocol to isolated aldoxime intermediates provided the corresponding nitriles with yields comparable to those using the one-pot procedure.

Synthesis of trisubstituted imidazoles by palladium-catalyzed cyclization of O-pentafluorobenzoylamidoximes: Application to amino acid mimetics with a C-terminal imidazole

(Chemical Equation Presented) 1-Benzyl-4-methylimidazoles with a range of substituents at the 2-position are prepared from O-pentafluorobenzoylamidoximes on treatment with catalytic amounts of Pd(PPh3)4 and triethylamine. The sequenc