146552-72-9

Basic information

• Product Name: Carbamic acid, [(1S)-1-(aminomethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester
• CAS NO: 146552-72-9
• Molecular Formula: C14H22N2O2
• Molecular Weight: 250.341
• Mol File: 146552-72-9.mol
• Article Data: 33

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-1-(aminomethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-1-(aminomethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester(146552-72-9)
• EPA Substance Registry System: Carbamic acid, [(1S)-1-(aminomethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester(146552-72-9)

Safety Data

• Hazardous Substances Data: 146552-72-9(Hazardous Substances Data)

Usage

General Description

Carbamic acid, [(1S)-1-(aminomethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester is an organic compound that belongs to the class of carbamic acid esters. It is derived from the reaction of carbamic acid with (1S)-1-(aminomethyl)-2-phenylethyl and 1,1-dimethylethyl. This chemical compound is commonly used in the pharmaceutical industry as a reagent in the synthesis of various drugs. It is also used as a stabilizer and intermediate in the production of pesticide and herbicide products. Additionally, it has potential applications in the fields of organic synthesis and chemical research due to its unique chemical properties and reactivity.

Upstream product

• 134557-74-7 tert-butyl [(2S)-1-azido-3-phenylpropan-2-yl]carbamate 
• 145625-14-5 (S)-2-(tert-butoxycarbonylamino)-3-phenylpropanal oxime 
• 99281-90-0 (S)-2-(tert-butoxycarbonylamino)-3-phenylpropanenitrile 
• 187526-92-7 [(1S)-1-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-2-phenylethyl]carbamic acid 1,1-dimethylethyl ester 
• 119153-87-6 (C₅H₉O₂)C₉H₉NO(O)(CO₂C₂H₅) 
• 88463-18-7 (S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 5241-58-7 L-Phenylalanine amide 
• 141403-49-8 (2S)-2-[N-(tert-butoxycarbonyl)amino]-3-phenyl-O-(4-methylphenylsulfonyl)propan-1-ol 
• 4522-04-7 ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalaninate 
• 126301-19-7 (2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate 
• 185384-15-0 (S)-tert-butyl (1-bromo-3-phenylpropan-2-yl)carbamate 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 3182-95-4 L-Phenylalaninol 

Downstream Products

• 1028273-37-1 {(S)-1-Benzyl-2-[3-(2,6-diisopropyl-phenyl)-ureido]-ethyl}-carbamic acid tert-butyl ester 
• 74822-65-4 (S)-(-)-1,2-diamino-3-phenylpropane dihydrochloride 
• 185384-17-2 [(S)-1-Benzyl-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-ethyl]-carbamic acid tert-butyl ester 
• 244778-28-7 (2-tert-butoxycarbonylamino-3-phenyl-propyl)-carbamic acid 4-nitro-phenyl ester 
• 359015-30-8 tert-Butyl-N-{(1S)-1-benzyl-2-[(4-nitrobenzoyl)amino]ethyl}carbamate 
• 909404-34-8 {1-[3-(2-tert-butoxycarbonylamino-3-phenyl-propyl)-thioureidomethyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 909404-39-3 {1-benzyl-2-[3-(3,5-bis-trifluoromethyl-phenyl)-thioureido]-ethyl}-carbamic acid tert-butyl ester 
• 1007877-59-9 C₁₈H₃₀N₂O₂ 

Relevant articles and documents

Enantiodivergent synthesis of Wieland-Miescher ketone analog mediated by a chiral pyridinylmethyl-amine derivative

A new enantiodivergent route to provide the Wieland-Miescher ketone analog (3b) bearing a 7-membered ring via the intramolecular aldol reaction of the trione (5) mediated by a single chiral pyridinylmethylamine derivative (13e) was established. Although the enantioselectivities of 3b were moderate, the complete inversion of the enantioselectivities was observed based on the amount of additional trifluoroacetic acid (TFA). The basicity of the nitrogen atom on the pyridine ring was very important for this enantiodivergent behavior.

LIBRARIES OF DIVERSE MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

The present disclosure relates to novel macrocyclic compounds and libraries thereof that are useful as research tools for drug discovery efforts. This disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the follo wing formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl g roup, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each opti onally having at least one substituent; R 3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent; and R 4 and R 5 e ach independently represent a hydrogen atom; and R 2 and R 4 may form a cyc lic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.