1468-84-4Relevant articles and documents
A rapid method for open-loop/oxidation based on substituted cyclobutanol cyclization reaction preparation Tetralone derivatives (by machine translation)
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Paragraph 0054-0055, (2019/03/31)
The invention discloses a method for quickly based on substituted cyclobutanol oxidation open-loop/cyclization reaction preparation Tetralone derivatives of the method, the method is that the aryl substituted cyclobutanol cerium amine in the nitric acid oxidation of a pot of reaction under the action of the generating Tetralone derivatives; this method has the advantages of fast response (30 seconds in the completion of the reaction), the operation is simple (the open reaction), mild reaction conditions, one-step reaction, does not need to use noble metal catalytic, the yield is high, can be expands the quantity reaction and the like, overcome in the prior art long reaction time, requires the use of a noble metal catalyst, more reaction steps, more byproducts and the like. (by machine translation)
Tandem Oxidative Ring-Opening/Cyclization Reaction in Seconds in Open Atmosphere for the Synthesis of 1-Tetralones in Water-Acetonitrile
Fang, Jingxian,Li, Lesong,Yang, Chu,Chen, Jinping,Deng, Guo-Jun,Gong, Hang
supporting information, (2018/11/23)
A mild and practical tandem oxidative ring-opening/cyclization reaction mediated by Ce4+ for the synthesis of 1-tetralones is presented. This rapid transformation was completed within 30 s and conducted in an open reactor at 0 °C in a water-acetonitrile mixture. Various cyclobutanol derivatives are transformed into desired products in good to high yields, and this reaction can be easily scaled up to the gram scale.
FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS
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Page/Page column 117; 118; 119; 120, (2015/07/16)
The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.