146912-63-2 Usage
Description
2-(S)-HYDROXY-4-OXO-4-PHENYL-BUTYRIC ACID, also known as 2-(S)-Hydroxy-4-oxo-4-phenylbutyrate, is an organic compound with the molecular formula C10H10O4. It is a white solid and is known for its potential applications in the pharmaceutical industry. 2-(S)-HYDROXY-4-OXO-4-PHENYL-BUTYRIC ACID is characterized by its unique structure, which includes a hydroxyl group, a carbonyl group, and a phenyl ring, making it a versatile building block for the synthesis of various bioactive molecules.
Uses
Used in Pharmaceutical Industry:
2-(S)-HYDROXY-4-OXO-4-PHENYL-BUTYRIC ACID is used as a key intermediate in the synthesis of benzothiophenes, benzofurans, and indoles. These compounds are known for their potential therapeutic applications in the treatment of insulin resistance and hyperglycemia, which are common conditions associated with diabetes and metabolic disorders.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-(S)-HYDROXY-4-OXO-4-PHENYL-BUTYRIC ACID serves as a valuable starting material for the preparation of various complex organic molecules. Its unique structure allows for further functionalization and modification, making it a useful building block in the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
Due to its structural diversity and potential applications, 2-(S)-HYDROXY-4-OXO-4-PHENYL-BUTYRIC ACID is also utilized in research and development laboratories. Scientists and researchers use this compound to study its chemical properties, reactivity, and potential interactions with other molecules, which can lead to the discovery of new drugs and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 146912-63-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,9,1 and 2 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 146912-63:
(8*1)+(7*4)+(6*6)+(5*9)+(4*1)+(3*2)+(2*6)+(1*3)=142
142 % 10 = 2
So 146912-63-2 is a valid CAS Registry Number.
146912-63-2Relevant articles and documents
Asymmetric synthesis of (S)-dihydrokavain from l-malic acid
Eskici, Mustafa,Karanfil, Abdullah,?zer, M. Sabih,Kabak, Yal??n,Durucasu, ?nci
supporting information, p. 2382 - 2390 (2018/10/20)
A practical and efficient asymmetric synthesis of (S)-dihydrokavain from known ethyl (S)-2-hydroxy-4-phenylbutanoate which is, in turn, readily available from l-malic acid as a cheap chiral pool material is described using regioselective ring-opening of the 1,2-cyclic sulfate with lithium-3,3,3-triethoxypropiolate and subsequent HgO/H2SO4-mediated lactonization as the key steps. Its opposite enantiomer (R)-dihydrokavain was also synthesized from d-malic acid using the same sequences of reactions for the purpose of optical purity determination.
Enantio- and regiospecific reduction of ethyl 4-phenyl-2,4-dioxobutyrate with baker's yeast: Preparation of (R)-HPB ester
Fadnavis, Nitin W.,Radhika, Kasiraman R.
, p. 3443 - 3447 (2007/10/03)
Ethyl 2,4-dioxo-4-phenylbutyrate obtained by condensation of acetophenone with diethyl oxalate is reduced enantio- and regiospecifically by baker's yeast in a diisopropyl ether/water two-phase system to give (-)-ethyl (R)-2-hydroxy-4-oxo-4-phenylbutyrate with an ee = 98% in 80% isolated yield. The hydroxyester was hydrogenated over Pd-C to obtain (-)-ethyl (R)-2-hydroxy-4-phenylbutyrate (HPB ester), an important intermediate for the synthesis of ACE inhibitors. Prolonged contact of the reduction product with baker's yeast produced 3-phenyl 3-oxo propanol in 90% yield.
Synthesis of homochiral 2-hydroxy acids
-
, (2008/06/13)
A process for the production of a homochiral 2-hydroxy carboxylic acid or salt thereof corresponding to general formula (I), wherein R represents one of formulae (II), (III), (IV), (V), wherein R' represents straight- or branched-chain alkyl or phenyl opt
