90940-54-8

Basic information

• Product Name: D-HOMOPHENYLALANINE ETHYL ESTER HYDROC&
• Synonyms: D-HOMOPHENYLALANINE ETHYL ESTER HYDROC&;(?)-Ethyl (R)-2-Amino-4-phenylbutyrate hydrochloride ;D-HOMOPHENYLALANIN-ETHYLESTER-HYDROCHLOR;D-homophenylalanineethylesterHCl;D-Homophenylalanine ethyl ester hydrochloride;(R)-ethyl 2-aMino-4-phenylbutanoate hydrochloride;Benzenebutanoic acid, a-aMino-, ethyl ester,hydrochloride (1:1), (aR)-;D-HoMophenylalanine ethyl ester Hydrcohloride
• CAS NO: 90940-54-8
• Molecular Formula: C₁₂H₁₇NO₂*ClH
• Molecular Weight: 243.72982
• Mol File: 90940-54-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• BRN: 8937583
• CAS DataBase Reference: D-HOMOPHENYLALANINE ETHYL ESTER HYDROC&(CAS DataBase Reference)
• NIST Chemistry Reference: D-HOMOPHENYLALANINE ETHYL ESTER HYDROC&(90940-54-8)
• EPA Substance Registry System: D-HOMOPHENYLALANINE ETHYL ESTER HYDROC&(90940-54-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 90940-54-8(Hazardous Substances Data)

Usage

Description

D-Homophenylalanine Ethyl Ester Hydrochloride is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds and is utilized as a research chemical for scientific investigations.

Uses

Used in Pharmaceutical Synthesis:
D-Homophenylalanine Ethyl Ester Hydrochloride is used as a synthetic intermediate for the production of (R)-2-amino-4-phenylbutan-1-ol, which is a crucial component in the synthesis of 2,6-bis[(4R)-4,5-dihydro-4-(2-phenylethyl)-2-oxazolyl]pyridine ligand. This ligand has potential applications in the development of new pharmaceutical agents.
Used in Research Applications:
D-Homophenylalanine Ethyl Ester Hydrochloride is also used as a valuable research chemical, enabling scientists to explore its properties and potential applications in various fields of study. Its role in research aids in the advancement of knowledge and the discovery of new uses in different industries.

Upstream product

• 371255-35-5 ethyl (R)-2-azido-4-phenylbutanoate 
• 115016-95-0 (S)-2-hydroxy-4-phenylbutanoic acid 
• 125639-64-7 (S)-ethyl 2-hydroxy-4-phenylbutyrate 
• 146912-63-2 (S)-2-hydroxy-4-oxo-4-phenylbutanoic acid 
• 129277-07-2 ethyl (S)-2-methanesulfonyloxy-4-phenylbutanoate 
• 71-43-2 benzene 
• 1012-05-1 D,L-homophenylalanine 

Downstream Products

• 1001646-78-1 C₁₉H₂₂N₂O₃ 
• 1001646-79-2 C₁₃H₁₉NO₄S 
• 1083407-32-2 N-(methyloxalyl)-D-phenylalanine methyl ester 
• 761373-40-4 (βR)-β-amino-benzenebutanol 
• 1316742-31-0 (-)-2-(R)-(2-aminobenzoylamino)-4-phenylbutyric acid ethyl ester 
• 1316742-38-7 (-)-2-(R)-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}-6-phenylbutyric acid ethyl ester 

Relevant articles and documents

Ethyl 2,4-dioxo-4-phenylbutyrate: A versatile intermediate for the large-scale preparation of enantiomerically pure α-hydroxy and α-amino acid esters

Starting from ethyl 2,4-dioxo-4-phenylbutyrate, both enantiomers of six enantiomerically pure α-hydroxy and α-amino acid esters (homophenylalanine derivatives) were prepared on >100 g scale. The key step involves a Pt-cinchona catalyzed enantioselective hydrogenation followed by enrichment via crystallization. All derivatives are commercially available.

Process for preparing antihypertensive 1-substituted cyclic lactam-2-carboxylic acids and their derivatives

Certain antihypertensive 1-substituted cyclic lactam-2-carboxylic acids and their derivatives are prepared by reacting an ester of the formula STR1 with a suitable derivative of the formula STR2