147283-78-1

Basic information

• Product Name: 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetic acid
• Synonyms: 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetic acid
• CAS NO: 147283-78-1
• Molecular Weight: 198.135
• Mol File: 147283-78-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetic acid(147283-78-1)
• EPA Substance Registry System: 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetic acid(147283-78-1)

Safety Data

• Hazardous Substances Data: 147283-78-1(Hazardous Substances Data)

Usage

Classification

Organic acid, nitro derivative of oxopyridine

Uses

Building block in the synthesis of biologically active compounds, potential use in pharmaceuticals and agrochemicals

Properties

Antimicrobial, anti-inflammatory

Potential risks

Health hazards, environmental risks due to nitro group

Precautions

Caution should be exercised in handling and use.

Upstream product

• 6332-56-5 2-hydroxy-3-nitropyridine 
• 147283-76-9 ethyl 3-nitro-2-oxo-1,2-dihydro-1-pyridylacetate 
• 105-36-2 ethyl bromoacetate 
• 171559-74-3 tert-butyl 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetate 
• 6332-56-5 3-nitropyridone 
• 79-11-8 chloroacetic acid 

Downstream Products

• 179524-57-3 t-butyl [3-nitro-2-oxo-4-(3-phenylpropyl)-1,2,3,4-tetrahydropyridyl]acetate 
• 147283-74-7 ethyl 3-amino-2-oxo-1,2-dihydro-1-pyridylacetate 

Relevant articles and documents

TRANSGLUTAMINASE 2 (TG2) INHIBITORS

Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit transglutaminase 2 (TG2). Also described herein are methods for using such TG2 inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from TG2 inhibition.

Glycogen phosphorylase inhibitory effects of 2-oxo-1,2-dihydropyridin-3-yl amide derivatives

Glycogen phosphorylase (GP) plays a crucial role in the conversion of glycogen to glucose-1-phosphate (and in turn glucose) and is a promising target for therapeutic intervention in diabetes. In this study we synthesized new derivatives of 2-oxo-1,2-dihyd

Investigation of the regioselectivity of alkylation of 3-nitropyridin-2(1H)-ones

Alkylation of 3-nitropyridin-2(1H)-ones in the presence of bases affords N-alkylated products and sometimes O-alkylated products. The yields and relative amounts of N- and O-alkylated products depend substantially on the size of the substituent at the C(6