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1481-27-2

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1481-27-2 Usage

Description

4'-Fluoro-2'-hydroxyacetophenone is a substituted acetophenone derivative characterized by its colorless to yellow liquid appearance. It is known for its ability to undergo biological Baeyer-Villiger oxidation to 4-fluorocatechol using whole cells of Pseudomonas fluorescens ACB. The crystals of this compound belong to the monoclinic crystal system and space group P21/n.

Uses

Used in Pharmaceutical Industry:
4'-Fluoro-2'-hydroxyacetophenone is used as an intermediate compound for the preparation of a series of 4'-fluoro-2'-hydroxychalcones. These chalcones are synthesized through aldol condensation with substituted aldehydes, followed by cyclization with hydrazine hydrate. This process is essential in the development of various pharmaceutical products due to the potential biological activities of the resulting chalcones.
Used in Chemical Research:
As a substituted acetophenone derivative, 4'-Fluoro-2'-hydroxyacetophenone is also utilized in chemical research for studying the properties and reactions of acetophenone derivatives. Its unique structure allows researchers to explore new synthetic pathways and potential applications in various fields, including material science and pharmaceuticals.

Preparation

Preparation by Fries rearrangement of 3-fluorophenyl acetate with aluminium chloride without solvent at 160–180° (75%) (88–90%).

Check Digit Verification of cas no

The CAS Registry Mumber 1481-27-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,8 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1481-27:
(6*1)+(5*4)+(4*8)+(3*1)+(2*2)+(1*7)=72
72 % 10 = 2
So 1481-27-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H7FO/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5H,2,4H2

1481-27-2 Well-known Company Product Price

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  • Alfa Aesar

  • (A16030)  4'-Fluoro-2'-hydroxyacetophenone, 98%   

  • 1481-27-2

  • 5g

  • 716.0CNY

  • Detail
  • Alfa Aesar

  • (A16030)  4'-Fluoro-2'-hydroxyacetophenone, 98%   

  • 1481-27-2

  • 25g

  • 3226.0CNY

  • Detail
  • Alfa Aesar

  • (A16030)  4'-Fluoro-2'-hydroxyacetophenone, 98%   

  • 1481-27-2

  • 100g

  • 10966.0CNY

  • Detail

1481-27-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4'-Fluoro-2'-hydroxyacetophenone

1.2 Other means of identification

Product number -
Other names 1-(4-Fluoro-2-hydroxyphenyl)ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1481-27-2 SDS

1481-27-2Relevant articles and documents

A practical synthesis of 2'-fluoro-4'-hydroxyacetophenone

Zhang, Xiao-Bo,Lu, Qun,Xu, Wei-Ming

, p. 419 - 421 (2009)

-

Discovery of novel 3-{[(5,5-dimethyl-4,5-dihydroisoxazol-3-yl)sulfonyl]methyl}benzo[d]isoxazole analogs as promising very long chain fatty acids inhibitors

Lin, Jian,Li, Yitao,Hu, Xiaoyun,Chi, Weilin,Zeng, Shuiming,Xu, Junxing

, p. 226 - 240 (2020/10/19)

Very long chain fatty acids (VLCFAs) are one of the most principal and promising targets for herbicides discovery. In order to explore and find novel VLCFAs inhibitors with higher herbicidal activity and improved crop safety, a variety of new 3-{[(5,5-dimethyl-4,5-dihydroisoxazol-3-yl)sulfonyl]methyl}benzo[d]isoxazole derivatives were reasonably designed and synthesized. The results of greenhouse experiments indicated that several compounds exhibited good herbicidal activity against Digitaria sanguinalis, Echinochloa crus-galli, and Setaria faberii at rates of 150 g ai/ha. Compounds g4 and h1 displayed promising herbicidal activity against D sanguinalis and E crus-galli at rates of 75 g ai/ha, which is better than commercial pyroxasulfone and S-metolachlor. Moreover, compound h1 displayed higher activity against E crus-galli, D sanguinalis, and S faberii than pyroxasulfone and S-metolachlor even at a rate of 37.5 and 18.75 g ai/ha. Furthermore, both of the compounds g4 and h1 were much safer to these tested crops, especially to rice, wheat and rape, at the rate of 150 g ai/ha than pyroxasulfone. Therefore, h1 may act as a new lead structure for novel herbicides discovery.

HETEROCYCLIC FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO

-

, (2020/03/02)

In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of

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