148515-21-3Relevant articles and documents
Enantioselective total synthesis of (+)-amabiline
Senter, Timothy J.,Fadeyi, Olugbeminiyi O.,Lindsley, Craig W.
, p. 1869 - 1871 (2012)
The first total synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile, is reported. This convergent, enantioselective synthesis proceeds in 15 steps (10-step longest linear sequence) in 6.2% overall yield and features
Total synthesis of a novel 2-thiabicyclo[3.2.0]heptan-6-one analogue of penicillin N
Ferguson, Amanda C.,Adlington, Robert M.,Martyres, Domnic H.,Rutledge, Peter J.,Cowley, Andrew,Baldwin, Jack E.
, p. 8233 - 8243 (2003)
A route has been developed which allows synthesis of novel cyclobutanone analogues of penicillin. This is illustrated by the synthesis of (1R,4R,5R,5′R,7S)-(1b) and (1S,4S,5S,5′R,7R)-7-[5′ -amino-5′-carboxy]pentanamido]-2-thiabicyclo[3.2.0] heptan-6-one-4-carboxylate (1a), an analogue of penicillin N. The key steps in the synthesis were the formation of the bicyclic structure via a [2+2] cycloaddition and the introduction of nitrogen at C7 via an intramolecular nitrene insertion.
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives against Gram-Negative Multidrug-Resistant Pathogens
Kong, Qidi,Pan, Wei,Xu, Heng,Xue, Yaru,Guo, Bin,Meng, Xin,Luo, Cheng,Wang, Ting,Zhang, Shuhua,Yang, Yushe
supporting information, p. 8644 - 8665 (2021/06/28)
Due to the poor permeability across Gram-negative bacterial membranes and the troublesome bacterial efflux mechanism, only a few GyrB/ParE inhibitors with potent activity against Gram-negative pathogens have been reported. Among them, pyrimido[4,5-b]indol
A Total synthesis of aliskiren starting from D-Tartrate diester
Kim, Ji Hei,Ko, Soo Y.
, p. 3777 - 3781 (2014/01/17)
A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid-Cis-Bis-Lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.
