149080-28-4

Basic information

• Product Name: 4-(4-FLUOROPHENYL)BUTAN-1-AMINE
• Synonyms: 4-(4-FLUOROPHENYL)BUTAN-1-AMINE;OTAVA-BB 1038743;4-Fluoro-benzenebutanamine
• CAS NO: 149080-28-4
• Molecular Formula: C₁₀H₁₄FN
• Molecular Weight: 167.22
• Mol File: 149080-28-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-FLUOROPHENYL)BUTAN-1-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-FLUOROPHENYL)BUTAN-1-AMINE(149080-28-4)
• EPA Substance Registry System: 4-(4-FLUOROPHENYL)BUTAN-1-AMINE(149080-28-4)

Safety Data

• Hazardous Substances Data: 149080-28-4(Hazardous Substances Data)

Upstream product

• 220728-25-6 2-[4-(4-fluorophenyl)butyl]isoindoline-1,3-dione 
• 40283-05-4 4-(4-fluorophenyl)-1-butanol 
• 589-06-0 4-(4-fluorophenyl)butanoic acid 
• 89326-70-5 1-bromo-4-(4-fluorophenyl)-butane 
• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 

Downstream Products

• 149080-13-7 3-[2-((1S,2R,3S,4R)-3-{4-[4-(4-Fluoro-phenyl)-butylcarbamoyl]-oxazol-2-yl}-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid methyl ester 

Relevant articles and documents

Synthesis of potent non-imidazole histamine H3-receptor antagonists

Histamine has been converted into a non-imidazole H3-receptor histamine antagonist by addition of a 4-phenylbutyl group at the N(α)-position followed by removal of the imidazole ring. The resulting compound, N-ethyl- N-(4-phenylbutyl)amine, remarkably has a Ki = 1.3 μM as an H3 antagonist. Using this as a lead compound, a novel series of homologous O and S isosteric tertiary amines was synthesised and structure-activity studies furnished N- (5-phenoxypentyl)pyrrolidine (Ki = 0.18 ± 0.10 μM, for [3H]histamine release from rat cerebral cortex synaptosomes) which, more importantly, was active in vivo. Substitution of NO2 into the para position of the phenoxy group gave N-(5-p-nitrophenoxypentyl)pyrrolidine, UCL 1972 (Ki= 39 ± 11 nM), ED50 = 1.1 ± 0.6 mg/kg per os in mice on brain tele-methylhistamine levels.