89326-70-5

Basic information

• Product Name: Benzene, 1-(4-bromobutyl)-4-fluoro-
• CAS NO: 89326-70-5
• Molecular Formula: C10H12BrF
• Molecular Weight: 231.108
• Mol File: 89326-70-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(4-bromobutyl)-4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(4-bromobutyl)-4-fluoro-(89326-70-5)
• EPA Substance Registry System: Benzene, 1-(4-bromobutyl)-4-fluoro-(89326-70-5)

Safety Data

• Hazardous Substances Data: 89326-70-5(Hazardous Substances Data)

Upstream product

• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 
• 110-52-1 1,4-dibromo-butane 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 332-42-3 (2-bromoethyl)-4-fluorobenzene 
• 105-53-3 diethyl malonate 
• 1693-05-6 ethyl 4-(4'-fluorophenyl)butanoate 
• 589-06-0 4-(4-fluorophenyl)butanoic acid 
• 1736-67-0 4-fluorophenylacetaldehyde 
• 20637-05-2 methyl 4-(4-fluorophenyl)butanoate 
• 352-13-6 4-flourophenylmagnesium bromide 
• 40283-05-4 4-(4-fluorophenyl)-1-butanol 

Downstream Products

• 54540-59-9 2(3,5-Dimethoxyphenyl)-6-(4-Fluorophenyl)Hexane 
• 112887-54-4 N-{4-[4-(4-Fluoro-phenoxy)-butyl]-morpholin-2-ylmethyl}-acetamide 
• 89326-71-6 ethyl 2-ethoxycarbonyl-6-(4'-fluorophenyl)hexanoate 
• 220728-25-6 2-[4-(4-fluorophenyl)butyl]isoindoline-1,3-dione 
• 149080-28-4 4-p-fluorophenylbutylamine 
• 1359849-90-3 1-(4-chlorophenyl)-4-(4-(4-fluorophenyl)butyl)piperazine 
• 149069-37-4 1-fluoro-4-(4-iodobutyl)benzene 
• 1348724-47-9 2-(4-(4-(4-fluorophenyl)butyl)piperazin-1-yl)pyrimidine 
• 129281-28-3 1-(4-(4-fluorophenyl)butyl)-4-(pyridin-2-yl)piperazine 
• 164668-08-0 4-(4'-chlorophenyl)-1-(4'-(4-fluorophenyl)butyl)piperidin-4-ol 
• 24678-13-5 lenperone 
• 3575-80-2 melperone 

Relevant articles and documents

Substrate and Catalyst Effects in the Enantioselective Copper-Catalysed C–H Insertion Reactions of α-Diazo-β-oxo Sulfones

Excellent enantioselectivities of up to 98 % ee are achieved by employing the copper-bis(oxazoline)-NaBARF catalyst system in the C–H insertion reactions of α-diazo-β-oxo sulfones. The influence of variation of the bis(oxazoline) ligand, copper salt, additive and substrate on both the efficiency and the enantioselectivities of these intramolecular C–H insertion reactions has been explored. Optimum enantioselectivities are achieved with phenyl and diphenyl ligands across the substrate series.

3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase

Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). Inhibitors with a novel structure core are essential for combating resistance associated with known IN inhibitors (INIs). We have previously disclosed a novel dual inhibitor scaffold of HIV IN and reverse transcriptase (RT). Here we report the complete structure-activity relationship (SAR), molecular modeling, and resistance profile of this inhibitor type on IN inhibition. These studies support an antiviral mechanism of dual inhibition against both IN and RT and validate 3-hydroxypyrimidine-2,4-diones as an IN inhibitor scaffold.

Indoles

A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R1, R2, R3, R4, and R5 each represent a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3. The compounds have serotonin antagonism. They are therefore clinically useful as medicaments, in particular, for treating, ameliorating, and preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.