15032-21-0

Basic information

• Product Name: 2-METHYL-4-PHENYLPYRIDINE
• Synonyms: 4-PHENYL-2-PICOLINE;2-METHYL-4-PHENYLPYRIDINE
• CAS NO: 15032-21-0
• Molecular Formula: C₁₂H₁₁N
• Molecular Weight: 169.22
• Mol File: 15032-21-0.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 265.4 °C at 760 mmHg
• Flash Point: 107.6 °C
• Appearance: /
• Density: 1.03 g/cm³
• Vapor Pressure: 0.0151mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 2-METHYL-4-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-4-PHENYLPYRIDINE(15032-21-0)
• EPA Substance Registry System: 2-METHYL-4-PHENYLPYRIDINE(15032-21-0)

Safety Data

• Hazardous Substances Data: 15032-21-0(Hazardous Substances Data)

Usage

Description

2-METHYL-4-PHENYLPYRIDINE, with the molecular formula C12H11N, is a pyridine derivative characterized by a methyl group at the 2-position and a phenyl group at the 4-position. This chemical compound is involved in various research and industrial applications, particularly in the development of pharmaceuticals and agrochemicals. Its interaction with biological systems suggests potential uses in drug development, and it may also be utilized in the synthesis of other complex organic compounds. However, the precise role and potential of 2-METHYL-4-PHENYLPYRIDINE in these fields are still under investigation.

Uses

Used in Pharmaceutical Development:
2-METHYL-4-PHENYLPYRIDINE is used as a chemical intermediate for the development of pharmaceuticals, leveraging its ability to interact with biological systems. This interaction is crucial for the compound's potential role in creating new drugs and therapies.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-METHYL-4-PHENYLPYRIDINE is used as a building block for the synthesis of various agrochemicals. Its structural properties make it a valuable component in the creation of compounds designed to protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
2-METHYL-4-PHENYLPYRIDINE is utilized as a key component in the synthesis of complex organic compounds. Its unique structure allows it to be a versatile building block in organic chemistry, contributing to the development of novel molecules with diverse applications.

InChI:InChI=1/C12H11N/c1-10-9-12(7-8-13-10)11-5-3-2-4-6-11/h2-9H,1H3

Upstream product

• 109-06-8 α-picoline 
• 100-59-4 phenylmagnesium chloride 
• 132819-55-7 2-Methyl-4-phenyl-4H-pyridine-1-carboxylic acid ethyl ester 
• 86801-39-0 2-Methyl-4-phenyl-4H-pyridine-1-carboxylic acid tert-butyl ester 
• 75-07-0 acetaldehyde 
• 98-86-2 acetophenone 
• 7664-41-7 ammonia 
• 1131-61-9 4-Phenylpyridine 1-oxide 
• 2999-74-8 dimethylmagnesium 
• 939-23-1 p-phenylpyridine 
• 86801-38-9 4-phenyl-1-(tert-butoxycarbonyl)-1,4-dihydropyridine 
• 18312-45-3 propan-2-one O-acetyl oxime 
• 104-55-2 3-phenyl-propenal 
• 660867-80-1 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Downstream Products

• 55218-70-7 4-Phenyl-2-picolin-1-oxid 
• 55218-73-0 2-(hydroxymethyl)-4-phenylpyridine 
• 83782-51-8 2-<<(p-bromophenyl)thio>methyl>-4-phenylpyridine 

Relevant articles and documents

-

-

Small organic molecules with tailored structures: Initiators in the transition-metal-free C-H arylation of unactivated arenes

Simple, small organic molecules containing nitrogen and oxygen atoms in their structures have been disclosed to catalyze transition-metal-free C-H arylation of unactivated arenes with aryl iodides in the presence of tBuOK. In this article, an optimized catalytically active molecule, (2-(methylamino)phenyl)methanol, was designed. A broad range of aryl iodides could be converted into the corresponding arylated products at 100 °C over 24 h with good to excellent yields. Mechanistic experiments verified that radicals participated in this catalytic transformation and that the cleavage of the aromatic C-H bond was not the rate determining step. A K+ capture experiment by 18-crown-6 emphasized the significance of the cation species of the strong base. Fourier transform infrared spectroscopy proved that the catalytic system was activated by the hydrogen bonds between small organic molecules and tBuOK. Also, a clear mechanism was proposed. This transition-metal-free method affords a promising system for efficient and inexpensive synthesis of biaryls via a user-friendly approach, as confirmed by scale-up experiments.

Transition-Metal-Free Regioselective Alkylation of Pyridine N-Oxides Using 1,1-Diborylalkanes as Alkylating Reagents

Reported herein is an unprecedented base-promoted deborylative alkylation of pyridine N-oxides using 1,1-diborylalkanes as alkyl sources. The reaction proceeds efficiently for a wide range of pyridine N-oxides and 1,1-diborylalkanes with excellent regioselectivity. The utility of the developed method is demonstrated by the sequential C?H arylation and methylation of pyridine N-oxides. The reaction also can be applied for the direct introduction of a methyl group to 9-O-methylquinine N-oxide, thus it can serve as a powerful method for late-stage functionalization.