55218-73-0 Usage
Description
2-Hydroxymethyl-4-phenylpyridine, also known as HPPH, is an organic chemical compound with the molecular formula C12H11NO. It features a pyridine ring with a hydroxymethyl and phenyl substituent, and has demonstrated promising photosensitizing properties, making it a candidate for use in photodynamic therapy for cancer treatment. Additionally, it has been investigated for its potential anti-inflammatory and antioxidant properties, positioning it as a valuable tool in medical research and the development of new treatments for various diseases.
Uses
Used in Photodynamic Therapy:
2-Hydroxymethyl-4-phenylpyridine is used as a photosensitizer for photodynamic therapy, specifically in the treatment of cancer. Its unique properties allow it to absorb light and generate reactive oxygen species, which can lead to the destruction of cancer cells while minimizing damage to surrounding healthy tissue.
Used in Medical Research:
HPPH is utilized as a research tool in the investigation of photodynamic therapy mechanisms and the development of new treatment strategies for various diseases. Its potential anti-inflammatory and antioxidant properties also make it a subject of interest for exploring its effects on other medical conditions.
Used in Pharmaceutical Development:
2-Hydroxymethyl-4-phenylpyridine holds promise as a component in the development of new pharmaceuticals, particularly for cancer treatment. Its photosensitizing properties and potential therapeutic effects are being studied to create more effective and targeted treatments for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 55218-73-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,2,1 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55218-73:
(7*5)+(6*5)+(5*2)+(4*1)+(3*8)+(2*7)+(1*3)=120
120 % 10 = 0
So 55218-73-0 is a valid CAS Registry Number.
55218-73-0Relevant articles and documents
Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms
Rammal, Fatima,Gao, Di,Boujnah, Sondes,Hussein, Aqeel A.,Lalevée, Jacques,Gaumont, Annie-Claude,Morlet-Savary, Fabrice,Lakhdar, Sami
, p. 13710 - 13717 (2020/11/30)
Considering the synthetic relevance of heteroarenes in various areas ranging from organic synthesis to medicinal chemistry, developing practically simple methodologies to access functionalized heteroarenes is of a significant value. Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation. The synthetic importance of the developed reactions is demonstrated by the synthesis of biologically relevant compounds. Electron paramagnetic resonance spectroscopy, quantum yield measurements, and density-functional theory calculations allowed us to understand reaction mechanisms of both photocatalytic reactions.
SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Preparation III.3, (2010/09/17)
The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease.