150989-57-4Relevant articles and documents
Concise syntheses of stereoisomeric hexahydroazepine derivatives related to the protein kinase inhibitor balanol
Roy, Sankar P.,Chattopadhyay, Shital K.
, p. 5498 - 5501 (2008/12/22)
A stereodivergent route to four stereoisomeric azepane derivatives related to the important protein kinase inhibitor balanol is developed which utilises (-)- or (+)-serine as starting material, and a ring-closing metathesis as the key ring forming step.
Total Synthesis of (-)-Balanol
Lampe, John W.,Hughes, Philip F.,Biggers, Christopher K.,Smith, Shelley H.,Hu, Hong
, p. 5147 - 5148 (2007/10/02)
(-)-Balanol, a fungal metabolite with potent protein kinase C inhibitory properties, has been prepared in a total synthesis which makes use of an anionic homo-Fries rearrangement approach to the benzophenone subunit and in which the azepane subunit is obt