15149-10-7

Basic information

• Product Name: ETHYLENE GLYCOL MONO-P-TOLYL ETHER
• Synonyms: YLOTHANE;4-(2-HYDROXYETHOXY)TOLUENE;2-(4-METHYLPHENOXY)ETHANOL;2-(P-TOLYLOXY)ETHANOL;ETHYLENE GLYCOL MONO-P-TOLYL ETHER;2-(4-methylphenoxy)-ethano;2-(p-Methylphenoxy)ethylalcohol;beta-Hydroxyethyl p-methylphenyl ether
• CAS NO: 15149-10-7
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.19
• EINECS: 239-209-9
• Product Categories: Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols
• Mol File: 15149-10-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 45°C
• Boiling Point: 123°C 8mm
• Flash Point: 114.3 °C
• Appearance: /
• Density: 1.058 g/cm³
• Vapor Pressure: 0.00522mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.30±0.10(Predicted)
• CAS DataBase Reference: ETHYLENE GLYCOL MONO-P-TOLYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYLENE GLYCOL MONO-P-TOLYL ETHER(15149-10-7)
• EPA Substance Registry System: ETHYLENE GLYCOL MONO-P-TOLYL ETHER(15149-10-7)

Safety Data

• Statements: 36/37/38-41
• Safety Statements: 26-36-39
• Hazardous Substances Data: 15149-10-7(Hazardous Substances Data)

Usage

General Description

Ethylene Glycol Mono-p-Tolyl Ether is a colorless to pale yellow liquid with a faint, sweet odor. It is commonly used as a solvent in various industries, including coatings, inks, and adhesives. It can also be found in some cleaning products and as a chemical intermediate in the production of other chemicals. It is considered to have low toxicity and is not known to cause skin irritation, although it can be harmful if ingested or inhaled in high concentrations. Ethylene Glycol Mono-p-Tolyl Ether is flammable and should be handled and stored with proper precautions to prevent fire or exposure.

InChI:InChI=1/C9H12O2/c1-8-2-4-9(5-3-8)11-7-6-10/h2-5,10H,6-7H2,1H3

Upstream product

• 75-21-8 oxirane 
• 106-44-5 p-cresol 
• 1121-70-6 sodium 4-methylphenoxide 
• 940-64-7 2-(4-methylphenoxy)acetic acid 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 
• 96-49-1 [1,3]-dioxolan-2-one 
• 445283-27-2 2-(2-p-tolyloxy-ethoxy)-tetrahydro-pyran 
• 108-39-4 3-methyl-phenol 
• 106-38-7 para-bromotoluene 
• 107-21-1 ethylene glycol 
• 624-31-7 4-tolyl iodide 

Downstream Products

• 31432-80-1 carbamic acid-(2-p-tolyloxy-ethyl ester) 
• 20764-35-6 1-chloro-2-(p-methyl)phenoxyethan 
• 104037-31-2 1-p-tolyloxy-2-vinyloxy-ethane 
• 2046-82-4 Sodium; p-tolyloxy-acetate 
• 87271-22-5 2-(p-tolyloxy)ethyl methanesulfonate 
• 62644-01-3 β-p-Tolyloxyaethyl-m-tolylcarbamat 
• 62643-90-7 β-p-Tolyloxyaethyl-o-tolylcarbamat 
• 18800-34-5 1-bromo-2-(4'-methylphenoxy)ethane 
• 90875-89-1 2-(4-methylphenoxy)ethoxymethyl chloride 

Relevant articles and documents

PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.

Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ inhibitors

The emergence and spread of multidrug-resistant strains of the human pathological bacteria are generating a threat to public health worldwide. In the current study, a series of PC190723 derivatives was synthesized and investigated for their antimicrobial activity. The compounds exhibited good activity against several Gram-positive bacteria as determined by comparison of diameters of the zone of inhibition of test compounds and standard antibiotics. Compound 9 with a fluorine substitution on the phenyl ring showed the best antibacterial activity in the series against M. smegmatis with the zone ratio of 0.62, and against S. aureus with the zone ratio of 0.44. The results from this study indicate that based on the unique 3-methoxybenzamide pharmacophore, compound 9 may represent a promising lead candidate against Gram-positive bacteria that are worthy of further investigation

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.