1515-98-6Relevant articles and documents
Ni-Catalyzed Enantioselective Benzylation of Secondary Phosphine Oxide
Cai, Wen-Qiang,Wei, Qi,Zhang, Qing-Wei
supporting information, p. 1258 - 1262 (2022/02/14)
A nickel-catalyzed benzylic substitution of secondary phosphine oxide was described, affording the dialkylated P-stereogenic tertiary phosphine oxides with high to excellent enantioselectivities. The reaction was performed under mild conditions with commercially available benzyl chlorides and bench stable secondary phosphine oxides, exhibiting broad functional group tolerance. It represented a practical example for the preparation of P-stereogenic phosphine compounds.
Synthesis of P-chiral, non-racemic phosphinylacetates via enzymatic resolution of racemates
Kielbasinski,Zurawinski,Pietrusiewicz,Zablocka,Mikolajczyk
, p. 564 - 572 (2007/10/03)
A series of racemic methyl phosphinylacetates was hydrolyzed in the presence of porcine liver esterase (PLE) under the kinetic resolution conditions to give the corresponding P-chiral phosphinylacetic acids and recovered esters in high enantiomeric purity (72-100% ee). The Jones' active site model was applied to explain the enantioselectivity of this reaction.
STEREOSPECIFIC REDUCTION OF DIASTEREOMERICALLY PURE MENTHYL PHOSPHINATES: A NEW ROUTE TO OPTICALLY ACTIVE PHOSPHINE OXIDES
Koide, Yasuhiro,Sakamoto, Atsushi,Imamoto, Tsuneo
, p. 3375 - 3376 (2007/10/02)
Diastereomerically pure menthyl phosphinates are stereospecifically reduced by lithium 4,4'-di-tert-butylbiphenylide.Subsequent treatment with alkyl halides affords phosphine oxides with high optical purity.
