154127-42-1 Usage
Description
(4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2-, also known as (S)-4-Hydroxy-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide, is a chemical compound with a unique structure that has found applications in the pharmaceutical industry. It is characterized by its ability to act as a reactant in the synthesis of specific drugs.
Uses
Used in Pharmaceutical Industry:
(4S)-1,1-dioxide-3,4-dihydro-4-hydroxy-2is used as a reactant for the preparation of Brinzolamide (AL-4862) [B677600], a topical carbonic anhydrase inhibitor. This application is due to its chemical properties that allow it to participate in the synthesis process, ultimately leading to the creation of a drug that can be used to treat certain medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 154127-42-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,1,2 and 7 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 154127-42:
(8*1)+(7*5)+(6*4)+(5*1)+(4*2)+(3*7)+(2*4)+(1*2)=111
111 % 10 = 1
So 154127-42-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H16N2O6S3/c1-18-4-2-3-12-6-8(13)7-5-9(20(11,14)15)19-10(7)21(12,16)17/h5,8,13H,2-4,6H2,1H3,(H2,11,14,15)/t8-/m1/s1
154127-42-1Relevant articles and documents
PROCESS FOR PREPARING BRINZOLAMIDE
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Page/Page column 15-16, (2010/10/03)
The present invention refers to the preparation and purification of brinzolamide as well as to novel compounds useful in such processes.
IMPROVED PROCESS FOR THE PREPARATION OF (R)-(+)-4-(ETHYIAMINO)-3,4-DIHYDRO-2-(3- METHOXYPROPYL)-2H-THIENO[3,2-E]-L,2-THIAZINE-6-SULFONAMIDE-L,L-DIOXIDE
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Page/Page column 25-26, (2008/12/05)
Disclosed herein is an improved process for the preparation of (R)-(+)-4- (Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6- sulfonamide- 1,1 -dioxide (Brinzolamide) and novel intermediates thereof.
Sulfonamides useful as carbonic anhydrase inhibitors
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, (2008/06/13)
Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.