154127-41-0 Usage
Description
3,4-Dihydro-2-(3-methoxypropyl)-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide is a complex organic compound characterized by its pale yellow thick oil appearance. It is an impurity found in Brinzolamide (B677600), which is a carbonic anhydrase inhibitor and an antiglaucoma agent. 3,4-Dihydro-2-(3-methoxypropyl)-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide plays a significant role in the pharmaceutical industry due to its association with Brinzolamide.
Uses
Used in Pharmaceutical Industry:
3,4-Dihydro-2-(3-methoxypropyl)-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide is used as an impurity in the production of Brinzolamide for the following reasons:
It is associated with the carbonic anhydrase inhibitor and antiglaucoma agent, Brinzolamide (B677600), which is utilized in the treatment of glaucoma and other ocular hypertension conditions.
Understanding the presence and effects of this impurity can help in optimizing the manufacturing process and ensuring the safety and efficacy of Brinzolamide as a pharmaceutical product.
Used in Research and Development:
3,4-Dihydro-2-(3-methoxypropyl)-4-oxo-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide is also used as a subject of study in research and development for the following reasons:
Investigating the properties and effects of this compound can contribute to the broader understanding of similar organic compounds and their potential applications in various fields.
Research on this impurity may lead to the discovery of new therapeutic agents or improvements in the existing treatment methods for glaucoma and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 154127-41-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,1,2 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 154127-41:
(8*1)+(7*5)+(6*4)+(5*1)+(4*2)+(3*7)+(2*4)+(1*1)=110
110 % 10 = 0
So 154127-41-0 is a valid CAS Registry Number.
154127-41-0Relevant articles and documents
PROCESS FOR THE PREPARATION OF BRINZOLAMIDE
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Page/Page column 8-9, (2011/06/10)
The present invention relates to a process for the preparation of Brinzolamide, or 2H-thieno[3,2-e]-1, 2-thiazin-6-sulfonamide, 4-(ethyl amino)-3, 4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide,(4R)- via intermediates 2,3-dihydro-4H-thieno[3,2-e]-1, 2-thiazin-4-ones, 1,1-dioxide. Further objects of the present invention are the intermediates mentioned above and other intermediates of the synthesis.
Sulfonamides useful as carbonic anhydrase inhibitors
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, (2008/06/13)
Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
