15430-52-1

Basic information

• Product Name: Propargylamine hydrochloride
• Synonyms: 3-AMINO-1-PROPYNE HYDROCHLORIDE;2-PROPYNYLAMINE HYDROCHLORIDE;2-PROPYNYL ACETATE;MONO-PROPARGYLAMINE HYDROCHLORIDE;prop-2-ynylamine hydrochloride;PROP-2-YNYLAMMONIUM CHLORIDE;PROPARGYL ACETATE;PROPARGYLAMINE HYDROCHLORIDE
• CAS NO: 15430-52-1
• Molecular Formula: C₃H₆N*Cl
• Molecular Weight: 91.54
• EINECS: 239-440-5
• Product Categories: Aliphatics;Various Intermediates;Acetylenes;Functionalized Acetylenes;Intermediates;Alkynes and Other Reagents;Chemical Biology;Conjugation Chemistry: Azides;Functionalized Alkynes;Alkynes;Building Blocks;Chemical Synthesis;Organic Building Blocks;Terminal
• Mol File: 15430-52-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 179-182 °C(lit.)
• Boiling Point: 27-28 °C(lit.)
• Flash Point: 91 °F
• Appearance: /Powder
• Density: 0.989 g/mL at 25 °C(lit.)
• Vapor Pressure: 76.8mmHg at 25°C
• Refractive Index: n20/D 1.417(lit.)
• Storage Temp.: 0-6°C
• Solubility: Methanol (Slightly), Water (Slightly)
• Water Solubility: Soluble in water (partly), methanol, and ethanol.
• Sensitive: Hygroscopic
• Stability: Moisture Sensitive Highly Toxic
• BRN: 3669858
• CAS DataBase Reference: Propargylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Propargylamine hydrochloride(15430-52-1)
• EPA Substance Registry System: Propargylamine hydrochloride(15430-52-1)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: UK5076000
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 15430-52-1(Hazardous Substances Data)

Usage

Description

Propargylamine hydrochloride is a light brown crystalline compound that serves as a valuable intermediate in the synthesis of various pharmaceuticals and pesticides. Its unique chemical structure allows it to be a versatile building block in the development of new drugs and agrochemicals.

Uses

Used in Pharmaceutical Industry:
Propargylamine hydrochloride is used as an intermediate for the synthesis of various drugs. It plays a crucial role in the development of medications that target a wide range of health conditions, contributing to the advancement of pharmaceutical research and innovation.
Used in Pesticide Industry:
Propargylamine hydrochloride is also utilized as an intermediate in the preparation of pesticides. Its incorporation into the formulation of these agrochemicals helps in the development of more effective and targeted pest control solutions, ultimately benefiting agriculture and food production.

InChI:InChI=1/C3H5N.ClH/c1-2-3-4;/h1H,3-4H2;1H

Upstream product

• 146039-12-5 N-propargyltriethoxyiminophosphorane 
• 85231-95-4 C₁₂H₂₂NO₅P 
• 848129-49-7 N-tritylprop-2-yn-1-amine 
• 106-96-7 propargyl bromide 
• 624-65-7 2-propynyl chloride 
• 2450-71-7 Propargylamine 
• 7223-50-9 N-propargylphthalimide 
• 92136-39-5 N-tert-Butoxycarbonyl-1-amino-3-propyne 

Downstream Products

• 42275-96-7 3-chloro-propionic acid prop-2-ynylamide 
• 60557-23-5 3-oxo-N-prop-2-ynyl-butanamide 
• 925893-61-4 maleic acid N-propargylmonoamide 
• 5221-66-9 2,2-diphenyl-N-prop-2-ynyl-acetamide 
• 5221-62-5 propargyl urea 
• 1464-98-8 N-(prop-2-yn-1-yl)benzamide 
• 52829-72-8 5-methylene-1,3-thiazolidine-2-thione 
• 56096-28-7 2-(N-prop-2-ynylamino)acetonitrile 
• 80672-64-6 2-(2,6-Dimethyl-1-propa-1,2-dienyl-1H-pyridin-4-ylidene)-indan-1,3-dione 
• 80672-63-5 -2 indanedione-1,3 
• 2763-93-1 5-Aminomethyl-3-bromoisoxazole 
• 65881-41-6 N-Acetylpropargylamine 
• 69042-21-3 (N-propargyl)-3-amino-2-cyclohexenone 
• 669062-18-4 4-iodo-N-(prop-2-ynyl)benzenesulfonamide 

Relevant articles and documents

Solvent-freeN-Boc deprotection byex situgeneration of hydrogen chloride gas

An efficient, scalable and sustainable method for the quantitative deprotection of thetert-butyl carbamate (N-Boc) protecting group is described, using down to near-stoichiometric amounts of hydrogen chloride gas in solvent-free conditions. We demonstrate theex situgeneration of hydrogen chloride gas from sodium chloride and sulfuric acid in a two-chamber reactor, introducing a straightforward method for controlled and stoichiometric release of HCl gas. The solvent-free conditions allow deprotection of a wide variety ofN-Boc derivatives to obtain the hydrochloride salts in quantitative yields. The procedure obviates the need for any work-up or purification steps providing an uncomplicated green alternative to standard methods. Due to the solvent-free, anhydrous conditions, this method shows high tolerance towards acid sensitive functional groups and furnishes expanded functional group orthogonality.

PREPARATION OF RASAGILINE AND SALTS THEREOF

The present invention relates to processes for the preparation of rasagiline mesylate. Also provided is rasagiline mesylate having 90 volume percent of the particles (D90) with sizes less than about 6 μm and processes for the preparation thereof.

A convenient method for the preparation of primary amines using tritylamine

A simple method for the preparation of primary amines by treating N-tritylamines with trifluoroacetic acid has been established. The N-tritylamines were prepared by the reaction of alkyl halides or alkyl p-toluenesulfonates with tritylamine, or by the reaction of alkyl bromides with lithium tritylamide.