154731-88-1

Basic information

• Product Name: (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanebutanoic acid
• CAS NO: 154731-88-1
• Molecular Weight: 285.384
• Mol File: 154731-88-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanebutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanebutanoic acid(154731-88-1)
• EPA Substance Registry System: (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanebutanoic acid(154731-88-1)

Safety Data

• Hazardous Substances Data: 154731-88-1(Hazardous Substances Data)

Usage

Description

(S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanebutanoic acid is a chemical compound with the molecular formula C16H29NO4. It is a derivative of cyclohexanebutanoic acid and contains a carbamate group. (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanebutanoic acid is characterized by its unique stereochemistry and functional groups, which contribute to its potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
(S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanebutanoic acid is used as a chiral building block for the synthesis of various biologically active compounds. Its unique structure allows for the creation of molecules with specific properties, making it a valuable asset in drug development.
Used in Antiviral and Antitumor Agents:
(S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanebutanoic acid is used as a precursor in the production of various drugs, particularly in the development of antiviral and antitumor agents. Its structural features enable the design of molecules that can target specific viral or tumor cells, potentially leading to more effective treatments.
Used in Medicinal Chemistry and Drug Discovery:
(S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]cyclohexanebutanoic acid has potential applications in the field of medicinal chemistry and drug discovery. Its unique properties and reactivity make it a promising candidate for the development of new therapeutic agents and the exploration of novel chemical spaces.

Upstream product

• 82732-07-8 Boc-L-homophenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7440-06-4 platinum 

Downstream Products

• 185525-70-6 [1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-3-cyclohexylpropyl]carbamic acid 1,1-dimethylethyl ester 

Relevant articles and documents

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes

This work reports the development of highly potent and selective inhibitors of the β5c catalytic activity of human constitutive proteasomes. The work describes the design principles, large hydrophobic P3 residue and small hydrophobic P1 residue, that led to the synthesis of a panel of peptide epoxyketones; their evaluation and the selection of the most promising compounds for further analyses. Structure-activity relationships detail how in a logical order the β1c/i, β2c/i, and β5i activities became resistant to inhibition as compounds were diversified stepwise. The most effective compounds were obtained as a mixture of cis- and trans-biscyclohexyl isomers, and enantioselective synthesis resolved this issue. Studies on yeast proteasome structures complexed with some of the compounds provide a rationale for the potency and specificity. Substitution of the N-terminus in the most potent compound for a more soluble equivalent led to a cell-permeable molecule that selectively and efficiently blocks β5c in cells expressing both constitutive proteasomes and immunoproteasomes.

Spiro piperidines and homologs which promote release of growth hormone

There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such spiro compounds as the active ingredient thereof are also disclosed.

CCK ANALOGS WITH APPETITE REGULATING ACTIVITY

The invention is directed to novel CCK analogs wherein Tryptophan and/or Phenylalamine are substituted with a radical which provides enhanced appetite suppressant activity to the peptide.