156022-76-3Relevant articles and documents
Asymmetric synthesis; XXXVII: Synthesis of 2,6-disubstituted piperazines from chiral non-racemic lactams
Schanen, Vincent,Cherrier, Marie-Pierre,De Melo, Sebastiào Jose,Quirion, Jean-Charles,Husson, Henri-Philippe
, p. 833 - 837 (2007/10/03)
General and convenient syntheses of optically active 2,6-disubstituted piperazines are described. The method is based on diastereoselective alkylation of lactam 8 derived from (R)-(-)-phenylglycinol followed by a regio- and diastereoselective functionalisation of carbamates 10c and 10d. This procedure allowed the preparation of new α-amino acids 15 and 16.