180285-12-5

Basic information

• Product Name: (R)-4-((R)-2-Hydroxy-1-phenyl-ethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester
• Synonyms: (R)-4-((R)-2-Hydroxy-1-phenyl-ethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 180285-12-5
• Molecular Weight: 320.432
• Mol File: 180285-12-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-4-((R)-2-Hydroxy-1-phenyl-ethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-((R)-2-Hydroxy-1-phenyl-ethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester(180285-12-5)
• EPA Substance Registry System: (R)-4-((R)-2-Hydroxy-1-phenyl-ethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester(180285-12-5)

Safety Data

• Hazardous Substances Data: 180285-12-5(Hazardous Substances Data)

Upstream product

• 156022-74-1 1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate 
• 180285-10-3 (R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(4,4,5,5-tetramethyl-1-phenyl-3-oxa-4-sila-hexyl)piperazin-3-one 
• 156022-73-0 1,1-dimethylethyl (R)-2,5-diaza-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate 
• 156022-75-2 (R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one 
• 156022-72-9 tert-butyl N-(2-{[(1R)-2-hydroxy-1-phenylethyl]amino}-2-oxoethyl)carbamate 
• 180285-08-9 1,1-dimethylethyl (R)-2,5-diaza-7-hydroxy-6-phenylheptanoate 
• 56613-80-0 D-2-phenylglycinol 
• 4530-20-5 BOC-glycine 
• 156022-76-3 (R)-4-((R)-2-Hydroxy-1-phenyl-ethyl)-2-methyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 180285-18-1 (2S,6R)-4-((R)-2-Methoxy-1-phenyl-ethyl)-6-methyl-piperazine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 75336-86-6 (2R)-methylpiperazine 
• 180285-14-7 (R)-4-((R)-2-Methoxy-1-phenyl-ethyl)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 156022-78-5 (R)-2-((R)-3-Methyl-piperazin-1-yl)-2-phenyl-ethanol 

Relevant articles and documents

Asymmetric synthesis; XXXVII: Synthesis of 2,6-disubstituted piperazines from chiral non-racemic lactams

General and convenient syntheses of optically active 2,6-disubstituted piperazines are described. The method is based on diastereoselective alkylation of lactam 8 derived from (R)-(-)-phenylglycinol followed by a regio- and diastereoselective functionalisation of carbamates 10c and 10d. This procedure allowed the preparation of new α-amino acids 15 and 16.