157028-15-4

Basic information

• Product Name: 4-(methoxymethoxy)-3,5-dimethylbenzaldehyde
• Synonyms: 4-(methoxymethoxy)-3,5-dimethylbenzaldehyde
• CAS NO: 157028-15-4
• Molecular Weight: 194.23
• Mol File: 157028-15-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-(methoxymethoxy)-3,5-dimethylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(methoxymethoxy)-3,5-dimethylbenzaldehyde(157028-15-4)
• EPA Substance Registry System: 4-(methoxymethoxy)-3,5-dimethylbenzaldehyde(157028-15-4)

Safety Data

• Hazardous Substances Data: 157028-15-4(Hazardous Substances Data)

Upstream product

• 13057-17-5 bromethyl methyl ether 
• 2233-18-3 4-hydroxy-3,5-dimethylbenzaldehyde 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 53360-89-7 2-amino-1-(3-chloro-phenyl)-ethanol 
• 1253731-85-9 2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one 
• 1253731-87-1 5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-7-[2-(pyridin-3-ylmethoxy)ethoxy]-3H-quinazolin-4-one 
• 1253731-82-6 7-(2-benzyloxy-ethoxy)-2-(4-hydroxy-3,5-dimethyl-phenyl)-5-methoxy-3H-quinazolin-4-one 
• 1253731-84-8 7-fluoro-5-methoxy-2-(4-methoxymethoxy-3,5-dimethylphenyl)-3H-quinazolin-4-one 
• 1357167-28-2 C₁₅H₂₃NO₄ 
• 1357167-27-1 C₁₁H₁₄O₄ 
• 1357167-26-0 C₉H₁₂N₂O₂ 
• 1218995-47-1 (E)-ethyl 3-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoate 
• 1312425-06-1 (E)-3-(4-(methoxymethoxy)-3,5-dimethylstyryl)-N-propylbenzamide 
• 1284215-31-1 (E)-3-(4-hydroxy-3,5-dimethylstyryl)-N-propylbenzamide 
• 1218995-41-5 (E)-S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate 
• 1218995-49-3 (E)-S-phenyl 3-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzothioate 
• 1218995-48-2 (E)-3-(4-(methoxymethoxy)-3,5-dimethylstyryl)benzoic acid 

Relevant articles and documents

TREATMENT OF DISEASES BY EPIGENETIC REGULATION

The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.

Peroxynitrite generation from a NO-releasing nitrobenzene derivative in response to photoirradiation

Photocontrollable ONOO- generation from a nitrobenzene derivative was demonstrated. The designed compound released NO in response to photoirradiation, and the resulting semiquinone reduced molecular oxygen to generate O2-; reaction of the two generated ONOO -, as confirmed with an ONOO- fluorescent probe, HKGreen-3.

Epigenetic multiple ligands: Mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (Sirtuin) inhibitors

A number of new compounds bearing two ortho-bromo- and ortho,ortho- dibromophenol moieties linked through a saturated/unsaturated, linear/(poly)cyclic spacer (compounds 1-9) were prepared as simplified analogues of AMI-5 (eosin), a recently reported inhibitor of both protein arginine and histone lysine methyltransferases (PRMTs and HKMTs). Such compounds were tested against a panel of PRMTs (RmtA, PRMT1, and CARM1) and against human SET7 (a HKMT), using histone and nonhistone proteins as a substrate. They were also screened against HAT and SIRTs, because they are structurally related to some HAT and/or SIRT modulators. From the inhibitory data, some of tested compounds (1b, 1c, 4b, 4f, 4j, 4l, 7b, and 7f) were able to inhibit PRMTs, HKMT, HAT, and SIRTs with similar potency, thus behaving as multiple ligands for these epigenetic targets (epi-MLs). When tested on the human leukemia U937 cell line, the epi-MLs induced high apoptosis levels [i.e., 40.7% (4l) and 42.6% (7b)] and/or massive, dose-dependent cytodifferentiation [i.e., 95.2% (1c) and 96.1% (4j)], whereas the single-target inhibitors eosin, curcumin, and sirtinol were ineffective or showed a weak effect.