1578190-85-8

Basic information

• Product Name: (1-(4-chlorophenyl)-1H-1,2,3-triazole-4-yl)methyl decanoate
• Synonyms: (1-(4-chlorophenyl)-1H-1,2,3-triazole-4-yl)methyl decanoate
• CAS NO: 1578190-85-8
• Molecular Weight: 363.887
• Mol File: 1578190-85-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1-(4-chlorophenyl)-1H-1,2,3-triazole-4-yl)methyl decanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1-(4-chlorophenyl)-1H-1,2,3-triazole-4-yl)methyl decanoate(1578190-85-8)
• EPA Substance Registry System: (1-(4-chlorophenyl)-1H-1,2,3-triazole-4-yl)methyl decanoate(1578190-85-8)

Safety Data

• Hazardous Substances Data: 1578190-85-8(Hazardous Substances Data)

Upstream product

• 3296-05-7 1-azido-4-chlorobenzene 
• 133902-66-6 1‐(4‐chlorophenyl)‐1H‐1,2,3‐triazole‐4‐yl‐methanol 
• 112-13-0 n-decanoyl chloride 

Relevant articles and documents

Searching for new drugs for Chagas diseases: triazole analogs display high in vitro activity against Trypanosoma cruzi and low toxicity toward mammalian cells

Chagas disease is one of the most relevant endemic diseases in Latin America caused by the flagellate protozoan Trypanosoma cruzi. Nifurtimox and benzonidazole are the drugs used in the treatment of this disease, but they commonly are toxic and present severe side effects. New effective molecules, without collateral effects, has promoted the investigation to develop new lead compounds with to advance for clinical trials. Previously, 3-nitro-1H-1,2,4-triazole-based amines and 1,2,3-triazoles demonstrated significant trypanocidal activity against T. cruzi. In this paper, we synthesized a new series of 92 examples of 1,2,3-triazoles. Six compounds exhibited antiparasitic activity, 14, 25, 27, 31 and 40, 43 and were effective against epimastigotes of two strains of T. cruzi (Y and Dm28-C) and 25, 27 and 31 exhibited trypanocidal activity similar to benzonidazole. Notably, the compound 25 compared to benzonidazole increase the toxicity against T. cruzi, with no apparent toxicity to the cell line of mice macrophages or primary mice peritoneal macrophages. As results, we calculated selectivity indexes up to 2000 to 25 and 31 in both T. cruzi strains. Derivative 14 caused a trypanostatic effect because it did not damage external epimastigote membrane. Triazoles 40 and 43 impaired parasites viability using a pathway not dependent on ROS production.

1-Phenyl-1H- and 2-phenyl-2H-1,2,3-triazol derivatives: Design, synthesis and inhibitory effect on alpha-glycosidases

Due to aging and increasingly overweight in human population, the incidence of non-insulin dependent diabetes mellitus (NIDDM or Type 2 DM) is increasing considerably. Therefore, searching for new α-glycosidase inhibitors (GIs) capable of slowing down carbohydrate assimilation by humans is an important strategy towards control of NIDDM. In this report, we disclose the search for new easily accessible synthetic triazoles as anti-diabetic compounds. Two series of non-glycosid triazoles were synthesized (series A and B) and screened against baker's yeast α-glucosidase (MAL12) and porcine pancreatic α-amylase activity (PPA). Of the 60 compounds tested at 500 μM, were considered hits (≥60% inhibition) six triazoles against MAL12 and three against PPA, with the inhibition reaching up to 99.4% on MAL12 and 88.6% on PPA. The IC50 values were calculated for both enzymes and ranged from 54 to 482 μM for MAL12 and 145 to 282 μM for PPA. These results demonstrated the potential activity of simple and non-glycosidic triazoles as an important novel class of GIs for the development of drugs to treat Type 2 DM.