15893-47-7Relevant articles and documents
Enzymatic stability of myostatin inhibitory 16-mer peptides
Hayashi, Yoshio,Odagiri, Miki,Taguchi, Akihiro,Takayama, Kentaro,Taniguchi, Atsuhiko
, p. 512 - 515 (2020/07/21)
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Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones
Otevrel, Jan,Svestka, David,Bobal, Pavel
supporting information, p. 5244 - 5248 (2019/06/07)
We have developed a catalytic system based on bianthrylbis(thiourea) for the asymmetric Henry reaction of fluoroketones and nitroalkanes that resulted from the screening of a library containing 31 chiral non-racemic organocatalysts. The corresponding adducts were isolated in up to 6 times shorter reaction time in comparison with the previously published organocatalysts. High levels of stereocontrol have been generally observed, with measured product enantiomeric excesses up to 97% and diastereomeric ratio 3:2 (anti/syn). The above-mentioned catalysts have been successfully applied to the total asymmetric synthesis of CF3-tethered (S)-halostachines, which has proved that this method constitutes an easy entry to similar enantiopure compounds.
3, 5-disubstituted hydantoin compound as well as preparation method and application thereof
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Paragraph 0041; 0051; 0052; 0063; 0064, (2018/10/19)
The invention provides a 3, 5-disubstituted hydantoin compound as well as a preparation method and an application thereof. The structure of the compound is shown in formula I in the description. The application of the 3, 5-disubstituted hydantoin compound shown in the formula I or solvates, hydrates or salts of the compound in preparation of medicines for treating Alzheimer's disease, vascular dementia and other dementia diseases with memory impairment also belongs to the protection scope. Animal experiments prove that the compound has the effect of saving memory of animal models, has high safety, does not have mutagenicity, can stay in blood for several hours after oral administration and intravenous injection, and can enter the brain.