159217-68-2Relevant articles and documents
Inhibition of 5-α-reductase (type-II) expression by antisense 3'- deoxy-(2'-5') oligonucleotide chimeras
Bhan, Purshotam,Bhan, Anila,Hong, Mikung,Hartwell, John G.,Saunders, June M.,Hoke, GlennD
, p. 1195 - 1199 (1997)
3'-Deoxy-(2'-5') oligonucleotides bind selectively to complementary RNA but not to DNA. 3'-Deoxy-(2'-5') phosphorothioate ODN chimeras embedded with a short stretch of 3'-5' phosphorothioate cassette are potent inhibitors of steroid 5-α-reductase expression with significantly less non-specific interactions in cell culture.