3608-58-0

Basic information

• Product Name: 3'-DEOXYGUANOSINE
• Synonyms: 3'-Deoxy-D-guanosine;3'-deoxyguanosine monohydrate;2-Amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-1H-purine-6(9H)-one;2-Amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-9H-purin-6(1H)-one;2-amino-9-[(2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one;2-amino-9-[(2R,3R,5S)-3-hydroxy-5-methylol-tetrahydrofuran-2-yl]-3H-purin-6-one;2-azanyl-9-[(2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one;2-AMino-9-((2R,3R,5S)-3-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
• CAS NO: 3608-58-0
• Molecular Formula: C₁₀H₁₃N₅O₄
• Molecular Weight: 267.24
• Product Categories: Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides
• Mol File: 3608-58-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: <300℃ (water )
• Boiling Point: 725.5 °C at 760 mmHg
• Flash Point: 392.6 °C
• Appearance: /
• Density: 2.08±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Water (Slightly, Heated, Sonicated)
• CAS DataBase Reference: 3'-DEOXYGUANOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-DEOXYGUANOSINE(3608-58-0)
• EPA Substance Registry System: 3'-DEOXYGUANOSINE(3608-58-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3608-58-0(Hazardous Substances Data)

Usage

Description

3'-Deoxyguanosine is a derivative of guanosine, a nucleoside that plays a crucial role in various biological processes. As a ligand, it can form complexes with enzymes such as purine nucleoside phosphorylase and receptors, making it a valuable tool for studying structure-activity relationships. 3'-DEOXYGUANOSINE is also known for its potential as an anti-amoebic agent and its ability to selectively impair transcription. With its solid chemical properties, 3'-deoxyguanosine offers a range of applications across different industries.

Uses

Used in Pharmaceutical Applications:
3'-Deoxyguanosine is used as a research compound for studying the interactions between ligands, enzymes, and receptors. Its ability to form complexes with purine nucleoside phosphorylase and receptors helps researchers understand the underlying mechanisms of various biological processes and develop targeted therapies.
Used in Antimicrobial Applications:
As a potential anti-amoebic agent, 3'-deoxyguanosine is used in the development of treatments for amoebic infections. Its ability to selectively impair transcription makes it a promising candidate for targeting and disrupting the life cycle of amoebic parasites.
Used in Biochemical Research:
3'-Deoxyguanosine is used as a tool in biochemical research to investigate the structure-activity relationships of various compounds. Its interaction with enzymes and receptors provides valuable insights into the design and optimization of new drugs and therapeutic agents.
Used in Drug Development:
3'-DEOXYGUANOSINE's ability to selectively impair transcription makes it a valuable asset in the development of new drugs targeting specific genetic pathways. Researchers can use 3'-deoxyguanosine to study the effects of transcription inhibition on cellular processes and develop novel therapeutic strategies for various diseases.

Downstream Products

• 159217-68-2 N'-(9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine 
• 157327-97-4 Diisopropyl-phosphoramidous acid (2R,3R,5S)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 157327-99-6 N-(9-((2R,3R,5S)-5-((bis(4-methoxyphenyl) (phenyl)methoxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide 
• 444019-18-5 N³-(p-anisyldiphenylmethyl)-3'-deoxyguanosine 
• 869355-04-4 N'-[9-((2R,3R,5S)-3-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine 

Relevant articles and documents

Synthesis of 2′,3′-dideoxypurinenucleosides via the palladium catalyzed reduction of 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)purine derivatives

Practical method to produce 2′,3′-dideoxypurinenucleosides from 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)purines (1) was developed. High ratio of 2′,3′-dideoxynucleoside to 3′-deoxyribonucleoside was obtained by selecting the reaction conditions (solvent, pH and/or base), or changing 2′-acyloxy leaving group. The reaction mechanism was studied by deuteration experiments of 1a and 1-(3,5-di-O-acetyl-2-bromo-2-deoxy-β-D-ribofuranosyl)thymine (12).