444019-18-5Relevant articles and documents
Synthesis and evaluation of S-Acyl-2-thioethyl esters of modified nucleoside 5′-monophosphates as inhibitors of hepatitis C virus RNA replication
Prakash, Thazha P.,Prhavc, Marija,Eldrup, Anne B.,Cook, P. Dan,Carroll, Steven S.,Olsen, David B.,Stahlhut, Mark W.,Tomassini, Joanne E.,MacCoss, Malcolm,Galloway, Sheila M.,Hilliard, Catherine,Bhat, Balkrishen
, p. 1199 - 1210 (2007/10/03)
Several triphosphates of modified nucleosides (1-6) were identified as inhibitors (IC50 -0.08-3.8 μM) of hepatitis C virus RNA-dependent RNA polymerase (RdRp). Although the initial SAR developed by determining the ability of the triphosphates t
