159870-91-4 Usage
Description
2-BROMO-6-FLUOROQUINOLINE, also known as 2-bromo-6-fluoro-1,4-dihydro-4-oxoquinoline, is a heterocyclic compound with the molecular formula C9H5BrFNO. It is a fluorinated quinoline derivative that is commonly used in pharmaceutical and chemical synthesis. This chemical is known for its antimicrobial, antimalarial, and anticancer properties, making it a valuable building block for the development of new drugs. Additionally, 2-BROMO-6-FLUOROQUINOLINE is often used as a precursor in the synthesis of diverse biologically active compounds, and it can also be employed as a fluorescent probe in biochemical studies. However, it is important to handle this chemical with caution, as it can be harmful if ingested or inhaled and may cause skin and eye irritation.
Uses
Used in Pharmaceutical Industry:
2-BROMO-6-FLUOROQUINOLINE is used as a building block for the development of new drugs due to its antimicrobial, antimalarial, and anticancer properties.
Used in Chemical Synthesis:
2-BROMO-6-FLUOROQUINOLINE is used as a precursor in the synthesis of diverse biologically active compounds.
Used in Biochemical Research:
2-BROMO-6-FLUOROQUINOLINE is used as a fluorescent probe in biochemical studies.
Check Digit Verification of cas no
The CAS Registry Mumber 159870-91-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,9,8,7 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 159870-91:
(8*1)+(7*5)+(6*9)+(5*8)+(4*7)+(3*0)+(2*9)+(1*1)=184
184 % 10 = 4
So 159870-91-4 is a valid CAS Registry Number.
159870-91-4Relevant articles and documents
Catalytic Enantioselective Synthesis of Heterocyclic Vicinal Fluoroamines by Using Asymmetric Protonation: Method Development and Mechanistic Study
Ashford, Matthew W.,Xu, Chao,Molloy, John J.,Carpenter-Warren, Cameron,Slawin, Alexandra M. Z.,Leach, Andrew G.,Watson, Allan J. B.
, p. 12249 - 12255 (2020)
A catalytic enantioselective synthesis of heterocyclic vicinal fluoroamines is reported. A chiral Br?nsted acid promotes aza-Michael addition to fluoroalkenyl heterocycles to give a prochiral enamine intermediate that undergoes asymmetric protonation upon rearomatization. The reaction accommodates a range of azaheterocycles and nucleophiles, generating the C?F stereocentre in high enantioselectivity, and is also amenable to stereogenic C?CF3 bonds. Extensive DFT calculations provided evidence for stereocontrolled proton transfer from catalyst to substrate as the rate-determining step, and showed the importance of steric interactions from the catalyst's alkyl groups in enforcing the high enantioselectivity. Crystal structure data show the dominance of noncovalent interactions in the core structure conformation, enabling modulation of the conformational landscape. Ramachandran-type analysis of conformer distribution and Protein Data Bank mining indicated that benzylic fluorination by this approach has the potential to improve the potency of several marketed drugs.
