22614-75-1

Basic information

• Product Name: 6-FLUOROQUINOLIN-2(1H)-ONE
• Synonyms: 6-FLUOROQUINOLIN-2(1H)-ONE;6-Fluoro-1H-quinolin-2-one;6-Fluoro-2-hydroxyquinoline;2(1H)-Quinolinone, 6-fluoro-;6-Fluoroquinolin-2(1H)
• CAS NO: 22614-75-1
• Molecular Formula: C9H6FNO
• Molecular Weight: 163.15
• Mol File: 22614-75-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 270-275 °C
• Boiling Point: 341.206 °C at 760 mmHg
• Flash Point: 160.156 °C
• Appearance: /
• Density: 1.292 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.58±0.70(Predicted)
• CAS DataBase Reference: 6-FLUOROQUINOLIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUOROQUINOLIN-2(1H)-ONE(22614-75-1)
• EPA Substance Registry System: 6-FLUOROQUINOLIN-2(1H)-ONE(22614-75-1)

Safety Data

• Hazardous Substances Data: 22614-75-1(Hazardous Substances Data)

Usage

General Description

6-FLUOROQUINOLIN-2(1H)-ONE, also known as 6-fluoro-1H-quinolin-2-one, is a chemical compound belonging to the quinolone class of molecules. It is a heterocyclic compound with a fluorine atom attached to the quinoline ring. 6-FLUOROQUINOLIN-2(1H)-ONE has been used in the synthesis of various pharmaceuticals and bioactive compounds, and it exhibits antibacterial and antifungal properties. It is also a valuable intermediate in the production of other fluorinated quinolone derivatives. The compound has potential applications in the pharmaceutical and agrochemical industries, making it a subject of interest for further research and development.

Upstream product

• 791626-56-7 (2E)-N-(4-fluorophenyl)-3-phenylacrylamide 
• 371-40-4 4-fluoroaniline 
• 19358-27-1 N-(4-fluorophenyl)-3-phenylacrylamide 
• 351-83-7 4'-fluoroacetanilide 
• 292638-85-8 acrylic acid methyl ester 
• 140-88-5 ethyl acrylate 
• 75893-82-2 6-fluoro-3,4-dihydro-1H-quinolin-2-one 
• 396-30-5 6-fluoroquinoline 
• 887903-01-7 4-fluoro-2-trimethylsilanylethynylphenylamine 
• 1895-39-2 sodium chlorodifluoroacetate 
• 452-71-1 4-fluor-2-methylaniline 
• 2338-74-1 6-fluoroquinoline N--oxide 
• 102-92-1 cinnamoyl chloride 

Downstream Products

• 77119-53-0 2-chloro-6-fluoro-quinoline 
• 791626-57-8 6-fluoroquinolin-2-amine 
• 159870-91-4 2--bromo--6-fluoroquinoline 

Relevant articles and documents

Efficient visible light mediated synthesis of quinolin-2(1H)-ones from quinolineN-oxides

Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline-N-oxides. This reagent free highly atom economical photocatalytic method, with low catalyst loading, high yield and no undesirable by-product, provides an efficient greener alternative to all conventional synthesis reported to date. The robustness of the methodology has been successfully demonstrated with easy scaling up to the gram scale.

Compound as potassium channel modulator

The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.

Selectfluor-mediated regioselective nucleophilic functionalization of N-heterocycles under metal- and base-free conditions

A practical and environmentally attractive methodology for the direct diversification of N-heterocycles at ambient temperature under open-air conditions was developed. The obvious advantage of the process is that no toxic reagent, transition metal, base or other additive is employed, thus greatly reducing costs, facilitating post-reaction neutralization and purification and minimizing the environmental impact.