1621527-31-8

Basic information

• Product Name: (3-(((R)-1-(5'-chloro-2'-fluoro-[1,1-biphenyl]-4-yl)-4-((S)-1-(((cyclohexyloxy)carbonyl)oxy)ethoxy)-4-oxobutan-2-yl)amino)-3-oxopropyl)phosphonic acid
• Synonyms: (3-(((R)-1-(5'-chloro-2'-fluoro-[1,1-biphenyl]-4-yl)-4-((S)-1-(((cyclohexyloxy)carbonyl)oxy)ethoxy)-4-oxobutan-2-yl)amino)-3-oxopropyl)phosphonic acid
• CAS NO: 1621527-31-8
• Molecular Weight: 614.004
• Mol File: 1621527-31-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-(((R)-1-(5'-chloro-2'-fluoro-[1,1-biphenyl]-4-yl)-4-((S)-1-(((cyclohexyloxy)carbonyl)oxy)ethoxy)-4-oxobutan-2-yl)amino)-3-oxopropyl)phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3-(((R)-1-(5'-chloro-2'-fluoro-[1,1-biphenyl]-4-yl)-4-((S)-1-(((cyclohexyloxy)carbonyl)oxy)ethoxy)-4-oxobutan-2-yl)amino)-3-oxopropyl)phosphonic acid(1621527-31-8)
• EPA Substance Registry System: (3-(((R)-1-(5'-chloro-2'-fluoro-[1,1-biphenyl]-4-yl)-4-((S)-1-(((cyclohexyloxy)carbonyl)oxy)ethoxy)-4-oxobutan-2-yl)amino)-3-oxopropyl)phosphonic acid(1621527-31-8)

Safety Data

• Hazardous Substances Data: 1621527-31-8(Hazardous Substances Data)

Upstream product

• 5962-42-5 3-phosphonopropionic acid 
• 352535-83-2 5-chloro-2-fluorophenylboronic acid 
• 331763-75-8 (R)-4-(4-bromophenyl)-3-((tert-butoxycarbonyl)amino)butanoic acid 
• 1621527-49-8 (R)-3-((tert-butoxycarbonyl)amino)-4-(5'-chloro-2'-fluoro-[1,1-biphenyl]-4-yl)butanoic acid 

Relevant articles and documents

SUBSTITUTED BISPHENYL BUTANOIC PHOSPHONIC ACID DERIVATIVES AS NEP INHIBITORS

The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of the compounds of the invention and a combination of pharmacologically active agents and a compound of the invention.