1636166-30-7

Basic information

• Product Name: methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate
• Synonyms: methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate
• CAS NO: 1636166-30-7
• Molecular Weight: 330.694
• Mol File: 1636166-30-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate(1636166-30-7)
• EPA Substance Registry System: methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate(1636166-30-7)

Safety Data

• Hazardous Substances Data: 1636166-30-7(Hazardous Substances Data)

Upstream product

• 344-65-0 1-bromo-4-chloro-2-(trifluoromethyl)benzene 
• 1636166-29-4 methyl 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine-4-carboxylate 
• 1112178-31-0 methyl-6-chloro-2-methylpyrimidine-4-carboxylate 

Downstream Products

• 1636166-31-8 6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carboxylic acid 
• 1636166-32-9 tert-butyl 4-(6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidine-4-carbonyl)piperazine-1-carboxylate 
• 1636166-33-0 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(piperazin-1-yl)methanone 
• 1636166-34-1 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4(methylsulfonyl)piperazin-1-yl)methanone 
• 1636166-35-2 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((2,4-dichlorophenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-36-3 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((2,3-dichlorophenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-37-4 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((2,6-dichlorophenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-38-5 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((3-fluoro-4-methylphenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-39-6 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((4-fluorophenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-40-9 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((2,5-dimethoxyphenyl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-41-0 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-((5-methylisoxazol-4-yl)sulfonyl)piperazin-1-yl)methanone 
• 1636166-42-1 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-(cyclopropylsulfonyl)piperazin-1-yl)methanone 
• 1636166-43-2 (6-(4-chloro-2-(trifluoromethyl)phenyl)-2-methylpyrimidin-4-yl)(4-(isopropylsulfonyl) piperazin-1-yl)methanone 

Relevant articles and documents

Synthesis, antibacterial, anthelmintic and anti-inflammatory studies of novel methylpyrimidine sulfonylpiperazine derivatives

A strategic synthesis of novel methylpyrimidine sulfonyl piperazines involving Suzuki coupling was designed and pharmacological activities of the compounds were evaluated. Reactions were carried out under conventional method and show good functional group transformations and high yields. Structures of the newly synthesized compounds were established by infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) and elemental analysis. The compounds were tested for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains, anthelmintic activity using Pheretima posthuma and anti-inflammatory activity involving carrageenan induced rat paw edema model. Some compounds were proven to be potent pharmacophores.