344-65-0

Basic information

• Product Name: 2-Bromo-5-chlorobenzotrifluoride
• Synonyms: Benzene,2-bromo-5-chloro-1-(trifluoromethyl)-;2-bromo-5-chloro-α,α,α-trifluorotoluene;2-Bromo-5-chlorobenzotrifluoride 99%;2-Bromo-5-chlorobenzotrifluoride99%;2-BROMO-5-CHLOROBENZOTRIFLUORIDE, 98+%;1-Bromo-4-chloro-2-(trifluoromethyl)benzene;2-BROMO-5-C;2-Bromo-5-chorobenzotrifluoride
• CAS NO: 344-65-0
• Molecular Formula: C₇H₃BrClF₃
• Molecular Weight: 259.45
• EINECS: -0
• Product Categories: Bromine Compounds;Chlorine Compounds;Fluorine Compounds
• Mol File: 344-65-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 18-20°C
• Boiling Point: 179-180 °C(lit.)
• Flash Point: 198°C
• Appearance: Clear colourless to slightly yellow liquid
• Density: 1.759 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.779mmHg at 25°C
• Refractive Index: n20/D 1.5080(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• BRN: 2448030
• CAS DataBase Reference: 2-Bromo-5-chlorobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-chlorobenzotrifluoride(344-65-0)
• EPA Substance Registry System: 2-Bromo-5-chlorobenzotrifluoride(344-65-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36-37-23
• WGK Germany: 3
• Hazardous Substances Data: 344-65-0(Hazardous Substances Data)

Usage

Description

2-Bromo-5-chlorobenzotrifluoride is an organic compound characterized by its clear, colorless to slightly yellow liquid appearance. It is a halogenated aromatic compound with a bromine atom at the 2nd position, a chlorine atom at the 5th position, and a trifluoromethyl group attached to the benzene ring.

Uses

Used in Pharmaceutical Industry:
2-Bromo-5-chlorobenzotrifluoride is used as an intermediate in the synthesis of various pharmaceutical compounds for its unique reactivity and structural properties. Its ability to participate in chemical reactions allows for the creation of a wide range of therapeutic agents.
Used in Chemical Synthesis:
2-Bromo-5-chlorobenzotrifluoride is used as a key building block in the preparation of complex organic molecules, such as 6-[4-chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine and 4,4′-dichloro-2,2′-bis(trifluoromethyl) diphenyl sulphone. These compounds have potential applications in various fields, including materials science and pharmaceuticals, due to their unique chemical and physical properties.
Used in Material Science:
In the field of material science, 2-Bromo-5-chlorobenzotrifluoride can be utilized as a precursor for the development of novel materials with specific properties, such as improved thermal stability, chemical resistance, or electronic characteristics. Its unique structure and reactivity make it a valuable component in the design and synthesis of advanced materials.

InChI:InChI=1/C7H3BrClF3/c8-6-2-1-4(9)3-5(6)7(10,11)12/h1-3H

Upstream product

• 98-15-7 3-chlorotrifluoromethylbenzene 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 98-16-8 3-trifluoromethylaniline 
• 351-36-0 N-acetyl-3-trifluoromethylbenzenamine 

Downstream Products

• 154521-75-2 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphoxide 
• 154521-76-3 4,4'-dichloro-2,2'-bis(trifluoromethyl)diphenyl sulphone 
• 1198181-39-3 (3S)-1-[4-chloro-2-(trifluoromethyl)phenyl]pyrrolidin-3-ol 
• 1198180-53-8 ({(3S)-1-[4-chloro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid 
• 1636166-30-7 methyl-6-(4-chloro-2-(trifluoro methyl)phenyl)-2-methyl pyrimidine-4-carboxylate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF SUBSTITUTED BENZOTRIHALIDE

The present invention provides a process for the preparation of compound of Formula I; wherein X is selected from the group consisting of fluorine, chlorine, bromine and iodine; Y is selected from X and -NR1R2; R1 and R1, independent of each other, are selected from the group consisting of hydrogen, C1-4 alkyl and –COR; R is C1-4 alkyl.