16529-06-9

Basic information

• Product Name: 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID
• Synonyms: 2-(1H-BENZOIMIDAZOL-2-YL)BENZOIC ACID;2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID;2-(2-CARBOXYPHENYL)BENZIMIDAZOLE;2-(1H-Benzo[d]iMidazol-2-yl)benzoic acid
• CAS NO: 16529-06-9
• Molecular Formula: C₁₄H₁₀N₂O₂
• Molecular Weight: 238.24
• Mol File: 16529-06-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 513.2°Cat760mmHg
• Flash Point: 264.2°C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 2.34E-11mmHg at 25°C
• Refractive Index: 1.717
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID(16529-06-9)
• EPA Substance Registry System: 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID(16529-06-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 16529-06-9(Hazardous Substances Data)

Usage

General Description

2-(1H-benzimidazol-2-yl) benzoic acid is a chemical compound with the molecular formula C14H10N2O2. It belongs to the class of benzoic acids and is a derivative of benzimidazole. 2-(1H-BENZIMIDAZOL-2-YL) BENZOIC ACID has been studied for its potential biological and pharmacological properties, including its anti-inflammatory and anti-tumor activities. It has also been investigated for its potential use in the development of new drugs with therapeutic applications. The presence of the benzimidazole group in the molecule gives this compound unique characteristics and makes it a promising target for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C14H10N2O2/c17-14(18)10-6-2-1-5-9(10)13-15-11-7-3-4-8-12(11)16-13/h1-8H,(H,15,16)(H,17,18)

Upstream product

• 85-44-9 phthalic anhydride 
• 95-54-5 1,2-diamino-benzene 
• 34442-94-9 N-(o-nitrophenyl)phthalimide 
• 858442-03-2 [2-(2-amino-phenyl)-4-oxo-1,2,3,4-tetrahydro-phthalazin-1-yl]-acetic acid 
• 64-17-5 ethanol 
• 119-67-5 o-carboxybenzaldehyde 
• 1780-94-5 2-(2'-imidazolyl)benzoic acid 
• 4506-62-1 N-(2-aminophenyl)phthalimide 
• 7297-65-6 2-((2-aminophenylamino)carbonyl) benzoic acid 
• 64-19-7 acetic acid 
• 248-72-6 11H-benzo[4,5]imidazo[2,1-a]isoindole 
• 7647-01-0 hydrogenchloride 
• 88-95-9 Phthaloyl dichloride 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Downstream Products

• 939409-06-0 2-(1H-benzimidazol-2-yl)-benzoic acid ethyl ester 
• 1148018-34-1 C₂₀H₁₃N₃O₃ 
• 2717-05-7 1,2-benzoylenebenzimidazole 
• 716-79-0 2-phenyl-1H-benzoimidazole 

Relevant articles and documents

Cu(OAc)2-Mediated benzimidazole-directed C-H cyanation using 2-(4-methylpiperazin-1-yl)acetonitrile as the cyano source

A new protocol for the Cu(OAc)2-mediated cyanation of arenes using benzimidazole as the directing group with 2-(4-methylpiperazin-1-yl)acetonitrile as the cyano source was developed. A series of cyano derivatives were facilely and conveniently obtained in moderate to good yields by using this method. The C-H activation catalytic system was originally applied to the C(sp2)-H cyanation of the aryl/heteroaryl to synthesize 2-(1H-benzo[d]imidazol-2-yl)aryl nitriles. There were 19 new compounds in the synthesized 20 cyanide products. In this reaction, 2-(4-methylpiperazin-1-yl)acetonitrile as the cyano source was originally employed in the C(sp2)-H cyanation of the arenes. In addition, a fluorescent material 5a was obtained by derivative reactions of the obtained cyanide product 3.

Wavelength dependent photoextrusion and tandem photo-extrusion reactions of ninhydrin bis-acetals for the synthesis of 8-ring lactones, benzocyclobutenes and orthoanhydrides

Ninhydrin bis-acetals give access to 8-ring lactones, benzocyclo-butenes and spirocyclic orthoanhydrides through photoextrusion and tandem photoextrusion reactions. Syntheses of fimbricalyxlactone B, isoshihunine and numerous biologically-relevant heteroc

SYNTHESIS METHOD OF IMIDAZOLES

PROBLEM TO BE SOLVED: To provide benzimidazoles with small number of processes at high selectivity and high purity. SOLUTION: A synthesis method of benzimidazoles synthesizes at least one of an imidazole derivative and a carboxy imidazole derivative by reacting a diamine derivative and at least one of a dicarboxylic acid derivative and a dicarboxylic acid anhydride derivative in subcritical water or in supercritical water. For example, in subcritical water or in supercritical water, by reacting o-phenylene diamine and at least one of phthalic acid and phthalic anhydride, 2-phenylbenzimidazole and 2-o-benzimidazole benzoate are synthesized. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT