248-72-6

Basic information

• Product Name: 11H-Isoindolo[2,1-a]benzimidazole
• Synonyms: 11H-Isoindolo[2,1-a]benzimidazol;Benzimidazole, o-benzylene-2,1-; NSC 163482; o-Benzylene-2,1-benzimidazole
• CAS NO: 248-72-6
• Molecular Formula: C14H10 N2
• Molecular Weight: 206.24
• Mol File: 248-72-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 11H-Isoindolo[2,1-a]benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 11H-Isoindolo[2,1-a]benzimidazole(248-72-6)
• EPA Substance Registry System: 11H-Isoindolo[2,1-a]benzimidazole(248-72-6)

Safety Data

• Hazardous Substances Data: 248-72-6(Hazardous Substances Data)

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 39145-59-0 o-phenylenediamine hydrochloride 
• 7664-93-9 sulfuric acid 
• 858442-03-2 [2-(2-amino-phenyl)-4-oxo-1,2,3,4-tetrahydro-phthalazin-1-yl]-acetic acid 
• 1418363-64-0 2-iodo-1-trityl-1H-benzimidazole 
• 27692-04-2 2-iodo-1H-benzo[d]imidazole 
• 312631-73-5 1-benzyl-2-iodo-1H-benzo[d]imidazole 
• 95-54-5 1,2-diamino-benzene 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 312631-76-8 1-(2-bromobenzyl)-1H-benzo[d]imidazole 
• 51-17-2 benzoimidazole 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 91-13-4 α,α'-dibromo-o-xylene 
• 1608149-21-8 2-(2-nitrophenyl)isoindoline 

Downstream Products

• 2717-05-7 1,2-benzoylenebenzimidazole 
• 16529-06-9 2-(2-carboxyphenyl)benzimidazole 

Relevant articles and documents

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1,1-Hydroboration of Fused Azole-Isoindole Analogues as an Approach for Construction of B,N-Heterocycles and Azole-Fused B,N-Naphthalenes

Three isoelectronic analogues of pyrido[2,1-a]isoindole have been found to undergo a facile 1,1-hydroboration with HBMes2 borane, which provides a new and convenient method for the synthesis of B,N-heterocycles 1a-3a in high yields. Compounds 1a-3a can undergo photoelimination upon irradiation at 300 nm, generating heterocycle-fused B,N-naphthalene molecules 1b-3b, which display distinct yellow-green and blue fluorescent colors, respectively. Compound 1a undergoes thermal elimination, producing 1b at 280°C, while compound 2a only undergoes partial elimination, forming 2b at 320°C. Compound 3a is thermally stable up to 320°C.

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Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling

Iridium-catalyzed acceptorless dehydrogenative coupling of tertiary amines and arylamines has been developed. A number of benzimidazoles were prepared in good yields. An iridium-mediated C-H activation mechanism is suggested. This finding represents a novel strategy for the synthesis of benzimidazoles.

Metal-free TEMPO-promoted C(sp3)-H amination to afford multisubstituted benzimidazoles

An efficient TEMPO-air/cat. TEMPO-O2 oxidative protocol was developed to synthesize multisubstituted or fused tetracyclic benzimidazoles via a metal-free oxidative C-N coupling between the sp3 C-H and free N-H of readily available N1-benzyl/alkyl-1,2-phenylenediamines.