16732-75-5 Usage
Description
6-Chloroindole-2-carboxylic acid is an organic compound characterized by its off-white solid appearance. It is a derivative of indole, a heterocyclic aromatic ring system, with a chlorine atom at the 6th position and a carboxylic acid group at the 2nd position. 6-Chloroindole-2-carboxylic acid is known for its potential applications in the synthesis of various heterocyclic compounds, particularly indole derivatives.
Uses
Used in Pharmaceutical Industry:
6-Chloroindole-2-carboxylic acid is used as a key intermediate in the synthesis of heterocyclic compounds, specifically indole derivatives. These derivatives are valuable for the treatment of disorders that result in the accumulation of oxalate, a condition that can lead to the formation of kidney stones and other health issues. The compound's unique structure allows for the development of new therapeutic agents that can target and alleviate the symptoms of such disorders.
Used in Chemical Research:
As a versatile building block, 6-Chloroindole-2-carboxylic acid is also utilized in chemical research for the development of novel indole-based compounds with potential applications in various fields, including material science, agrochemistry, and pharmaceuticals. Its reactivity and functional groups make it an attractive candidate for further modification and exploration of its properties and potential uses.
Check Digit Verification of cas no
The CAS Registry Mumber 16732-75-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,3 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 16732-75:
(7*1)+(6*6)+(5*7)+(4*3)+(3*2)+(2*7)+(1*5)=115
115 % 10 = 5
So 16732-75-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H6ClNO2/c10-6-2-1-5-3-8(9(12)13)11-7(5)4-6/h1-4,11H,(H,12,13)
16732-75-5Relevant articles and documents
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Fox,Bullock
, p. 2756,2758 (1951)
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Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs
Hayashi, Shigeo,Ueno, Naomi,Murase, Akio,Takada, Junji
, p. 846 - 867 (2015/02/19)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage and hyper sensitivity owing to their COX-1 inhibition. Also, COX-2 inhibition-derived suppressive or preventive effects against initiation/proliferation/invasion/motility/recurrence/metastasis of various cancers/tumours such as colon, gastric, skin, lung, liver, pancreas, breast, prostate, cervical and ovarian cancers are significant. In this study, design, synthesis and structure-activity relationship (SAR) of various novel {2-[(2-, 3- and/or 4-substituted)-benzoyl, (bicyclic heterocycloalkanophenyl)carbonyl or cycloalkanecarbonyl]-(5- or 6-substituted)-1H-indol-3-yl}acetic acid analogues were investigated to seek and identify various chemotypes of potent and selective COX-2 inhibitors for the treatment of inflammatory diseases, resulting in the discovery of orally potent agents in the peripheral-inflammation model rats. The SARs and physicochemical properties for the analogues are described as significant findings. For graphical abstract: see Supplementary Material. (www.informahealthcare.com/enz)
INDOLOYLGUANIDINE DERIVATIVES
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, (2008/06/13)
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