540523-98-6

Basic information

• Product Name: 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester
• Synonyms: 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester
• CAS NO: 540523-98-6
• Molecular Weight: 271.657
• Mol File: 540523-98-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester(540523-98-6)
• EPA Substance Registry System: 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester(540523-98-6)

Safety Data

• Hazardous Substances Data: 540523-98-6(Hazardous Substances Data)

Upstream product

• 89-59-8 4-chloro-2-nitrotoluene 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 27034-51-1 ethyl 6-chloro-1H-indole-2-carboxylate 
• 1067657-84-4 6-chloro-3-(1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl)-1H-indole-2-carboxylic acid 
• 43142-81-0 ethyl 6-chloro-1-methyl-1H-indole-2-carboxylate 
• 16732-75-5 6-chloro-1H-indole-2-carboxylic acid 
• 53590-59-3 6-chloro-1H-indole-2-carbaldehyde 
• 53590-58-2 (6-chloro-1H-indol-2-yl)methanol 
• 540524-03-6 methyl 4-{2-[2-{2-[(benzylsulfonyl)amino]ethyl}-6-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate 
• 540524-02-5 N-{2-[6-chloro-1-(diphenylmethyl)-1H-indol-2-yl]ethyl}-1-phenylmethanesulfonamide 
• 540524-01-4 {2-[6-chloro-1-(diphenylmethyl)-1H-indol-2-yl]ethyl}amine 

Relevant articles and documents

Synthesis and in vitro characterization of novel fluorinated derivatives of the TSPO 18 kDa ligand SSR180575

Abstract SSR180575 (1) is a high-affinity (0.83 nM) TSPO 18 kDa ligand belonging to the pyridazino[4,5-b]indole-1-acetamides family. Herein we describe the synthesis and in vitro characterization of two series of new fluorinated analogues. Eleven compounds (out of fifteen) displayed nanomolar to subnamolar affinities (0.30-8.1 nM) and high selectivities (Ki(CBR)/Ki(TSPO) > 103). Two derivatives stand out as promising candidates for drug development or use as PET probes for in vivo neuroinflammation imaging, once fluorine-18-labelled.

NOVEL P53-MDM2/P53-MDM4 ANTAGONISTS TO TREAT PROLIFERATIVE DISEASE

High-resolution structural information delineates key interactions between MDM2 or MDM4 and heterocyclic compounds that bind to these proteins. These compounds are potent agonists of the p53-MDM2/p53-MDM4 complex.

Methods for the use of inhibitors of cytosolic phospholipase A2 in the treatment of thrombosis

This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds in the treating or preventing thrombosis in a mammal, or preventing progression of symptoms of thrombosis.