16821-32-2Relevant articles and documents
Intramolecular alkylations of aromatic compounds, XXIII: synthesis of methyl-4,5,6,6a,7a,8,9,10,11,11a-decahydro-7H-naphtho(1,8-fg)-isoquinolines
Reimann,Hargasser
, p. 159 - 164 (1989)
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Long,Burger
, p. 852,854 (1941)
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Woodward,Eastman
, p. 674,677 (1944)
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Design of Ru(II)-NHC-Diamine Precatalysts Directed by Ligand Cooperation: Applications and Mechanistic Investigations for Asymmetric Hydrogenation
Daniliuc, Constantin G.,Glorius, Frank,Hellmann, Lars,Li, Wei,Mück-Lichtenfeld, Christian,Neugebauer, Johannes,Wagener, Tobias
supporting information, p. 7100 - 7107 (2020/05/18)
A modular synthesis of Ru(II)-NHC-diamine complexes from readily available chiral N-heterocyclic carbenes (NHCs) and chiral diamines is disclosed for the first time. The well-defined Ru(II)-NHC-diamine complexes show unique structure and coordination chem
Deoxyfluorination with CuF2: Enabled by Using a Lewis Base Activating Group
Bode, Bela E.,Chabbra, Sonia,Champion, Sue,Dawson, Daniel M.,Sood, D. Eilidh,Sutherland, Andrew,Watson, Allan J. B.
supporting information, p. 8460 - 8463 (2020/04/10)
Deoxyfluorination is a primary method for the formation of C?F bonds. Bespoke reagents are commonly used because of issues associated with the low reactivity of metal fluorides. Reported here is the development of a simple strategy for deoxyfluorination, using first-row transition-metal fluorides, and it overcomes these limitations. Using CuF2 as an exemplar, activation of an O-alkylisourea adduct, formed in situ, allows effective nucleophilic fluoride transfer to a range of primary and secondary alcohols. Spectroscopic investigations have been used to probe the origin of the enhanced reactivity of CuF2. The utility of the process in enabling 18F-radiolabeling is also presented.