16939-04-1

Basic information

• Product Name: (4-THIEN-2-YLPHENYL)METHANOL
• Synonyms: 4-(Thien-2-yl)benzyl alcohol;2-p-Tolylthiophene;2-p-Tolyl-thiophene(7CI,8CI);(4-(Thiophen-2-yl)phenyl)Methanol;4-(Thien-2-yl)toluene, 1-Methyl-4-(thien-2-yl)benzene
• CAS NO: 16939-04-1
• Molecular Formula: C₁₁H₁₀S
• Molecular Weight: 190.2615
• Mol File: 16939-04-1.mol
• Article Data: 97

Chemical Properties

• Boiling Point: 338.5 °C at 760 mmHg
• Flash Point: 158.5 °C
• Appearance: /
• Density: 1.204 g/cm³
• Vapor Pressure: 3.8E-05mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: Room temperature.
• CAS DataBase Reference: (4-THIEN-2-YLPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-THIEN-2-YLPHENYL)METHANOL(16939-04-1)
• EPA Substance Registry System: (4-THIEN-2-YLPHENYL)METHANOL(16939-04-1)

Safety Data

• Hazard Codes: Harmful:
• Hazardous Substances Data: 16939-04-1(Hazardous Substances Data)

Usage

General Description

(4-thien-2-ylphenyl)methanol, also known as 2-(4-thien-2-ylphenyl)ethanol, is a chemical compound consisting of a thienylphenyl group attached to a methanol molecule. It is commonly used as a building block in the synthesis of numerous pharmaceuticals and organic compounds, due to its versatile chemical properties and reactivity. (4-THIEN-2-YLPHENYL)METHANOL has shown potential for various applications in organic synthesis, including the preparation of ketones, esters, and amines. Additionally, (4-thien-2-ylphenyl)methanol has been investigated for its biological activities, such as its potential as an antimicrobial and anti-inflammatory agent. Its unique structure and potential applications make it a valuable chemical compound in the field of organic chemistry and medicinal research.

InChI:InChI=1/C11H10OS/c12-8-9-3-5-10(6-4-9)11-2-1-7-13-11/h1-7,12H,8H2

Upstream product

• 188290-36-0 thiophene 
• 51274-57-8 1-(4-Methylphenyl)-3,3-(1,5-pentanediyl)triazene 
• 96-43-5 2-thienyl chloride 
• 108-88-3 toluene 
• 54663-78-4 tributyl(thien-2-yl)stannane 
• 3027-21-2 dimethoxy(methyl)phenylsilane 
• 624-31-7 4-tolyl iodide 
• 17881-88-8 methoxydimethylphenylsilane 
• 696-61-7 4-tolylmagnesium chloride 
• 1003-09-4 2-bromothiophene 
• 5720-05-8 4-methylphenylboronic acid 
• 1026668-29-0 bis(2-thiophenyl)iodonium tosylate 
• 106-49-0 p-toluidine 
• 3437-95-4 2-Iodothiophene 

Downstream Products

• 101093-85-0 4-oxo-4-[5-(p-tolyl)-2-thienyl]butanoic acid 
• 859055-63-3 1-(5-p-tolyl-[2]thienyl)-propan-1-one 
• 855631-70-8 phenyl[5-(4-methylphenyl)thiophene-2-yl]methanone 
• 860367-85-7 (4-methoxy-phenyl)-(5-p-tolyl-[2]thienyl)-ketone 
• 51335-91-2 1-[5-(4-methylphenyl)thiophene-2-yl]ethanone 
• 854468-05-6 1-(5-p-tolyl-[2]thienyl)-butan-1-one 
• 845753-53-9 2-bromo-5-(4-methylphenyl)thiophene 
• 83495-22-1 5,5'-Di-p-tolyl-[2,3']bithiophenyl 
• 38401-68-2 5-(4-methylphenyl)thiophene-2-carbaldehyde 
• 61100-11-6 ethyl 5-(p-tolyl) thiophene-2-carboxylate 
• 40808-21-7 5-(4-methylphenyl)thiophene-2-carboxylic acid 
• 184041-10-9 5-(4'-methylphenyl)-thiophene-2-sulfonyl chloride 

Relevant articles and documents

Bulk TiPd alloys as easily recyclable and preactivation-free heterogeneous catalysts for cross-coupling reactions

TiPd alloys have been found to be novel heterogeneous palladium catalysts for organic cross-coupling reactions. Catalyst preactivation is not necessary, resulting in facile recovery and reuse of the catalysts. Palladium is not leached into the reaction solution and the catalysts can be recycled several times without losing their catalytic activity.

4-Amino-1,2,4-triazoles-3-thiones and 1,3,4-oxadiazoles-2-thiones·palladium(II) recoverable complexes as catalysts in the sustainable Suzuki-Miyaura cross-coupling reaction

The Suzuki-Miyaura cross-coupling reaction using 4-amino-1,2,4-triazoles and 1,3,4-oxadiazoles-2-thiones·palladium (II) is studied. The reaction is optimized and the most appropriate catalytic complex is tested with several aryl halides, boronic acids in an environmentally benign solvent system (H2O/EtOH). The recovery of the catalytic species is also surveyed because of the nature of the employed solvent. A domino process is efficiently carried out following the standard conditions. Several surface parameters of the ligands are analyzed and the resulting values are extrapolated to the insoluble palladium catalyst.

Catalytic C-H arylation of unactivated heteroaromatics with aryl halides by cobalt porphyrin

Direct C-H arylation of unactivated heteroaromatics with aryl halides catalyzed by cobalt porphyrin is reported. The reaction is proposed to go through a homolytic aromatic substitution reaction. The aryl radical is electrophilic and a SOMO-HOMO interaction is predominant in the aryl radical addition process.

Suzuki-Miyaura Cross-Coupling Reaction with Potassium Aryltrifluoroborate in Pure Water Using Recyclable Nanoparticle Catalyst

This paper describes the Suzuki Miyaura cross-coupling reaction of aryl bromides with potassium aryltrifluoroborates in water catalyzed by linear polystyrene-stabilized PdO nanoparticles (PSPdONPs). The reaction of aryl bromides having electron-withdrawing groups or electron-donating groups took place smoothly to give the corresponding coupling product in high yields. The catalyst recycles five times without significant loss of catalytic activity although a little bit increase in size of PdNPs was observed after the reaction.

One-step synthesis of magnetically recyclable palladium loaded magnesium ferrite nanoparticles: application in synthesis of anticancer drug PCI-32765

Novel Palladium nanoparticles supported nano Magnesium ferrite catalyst (Pd/MgFe2O4) was synthesized by one-step ultrasound assisted coprecipitation. In-situ formed by-products assisted salt cage calcination approach was employed to