61100-11-6

Basic information

• Product Name: 2-Thiophenecarboxylic acid, 5-(4-methylphenyl)-, ethyl ester
• Synonyms: 5-p-tolyl-thiophene-2-carboxylic acid ethyl ester;2-Thiophenecarboxylic acid,5-(4-methylphenyl)-,ethyl ester
• CAS NO: 61100-11-6
• Molecular Formula: C14H14O2S
• Molecular Weight: 246.33
• Mol File: 61100-11-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Thiophenecarboxylic acid, 5-(4-methylphenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylic acid, 5-(4-methylphenyl)-, ethyl ester(61100-11-6)
• EPA Substance Registry System: 2-Thiophenecarboxylic acid, 5-(4-methylphenyl)-, ethyl ester(61100-11-6)

Safety Data

• Hazardous Substances Data: 61100-11-6(Hazardous Substances Data)

Upstream product

• 40808-08-0 1-Chlor-1-p-tolyl-propen-3-al 
• 623-51-8 ethyl 2-sulfanylacetate 
• 38401-68-2 5-(4-methylphenyl)thiophene-2-carbaldehyde 
• 16939-04-1 2-p-tolylthiophene 
• 40808-21-7 5-(4-methylphenyl)thiophene-2-carboxylic acid 
• 64-17-5 ethanol 
• 649569-55-1 thioacetic acid S-(4-oxo-4-p-tolyl-butyl) ester 
• 108-88-3 toluene 
• 38425-26-2 4-chloro-1-(4-methylphenyl)butan-1-one 

Downstream Products

• 62403-12-7 5-(4-methylphenyl)thiophene-2-carbohydrazide 

Relevant articles and documents

Base catalyzed reaction of ethyl thioglycolate with β-aryl-β-(methylthio) acroleins: A general method for the synthesis of 2-carbethoxy-5-substituted/4,5-annulated thiophenes in high overall yields

(Methylthio) acroleins 1a-m were shown to be stable unlike their counterpart the chloroacroleins and their efficacy as 1,3-dielectrophilic properties have now been examined successfully in this work. They are shown to react with ethyl thioglycolate in the

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.