17228-98-7

Basic information

• Product Name: 2-(4-CHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
• Synonyms: BUTTPARK 99\50-64;2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID;2-(4-CHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-(4-Chlorophenyl)-1,3-thiazole-4-carboxylic acid, 97+%
• CAS NO: 17228-98-7
• Molecular Formula: C₁₀H₆ClNO₂S
• Molecular Weight: 239.68
• Mol File: 17228-98-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 187-190°C
• Boiling Point: 441.9 °C at 760 mmHg
• Flash Point: 221 °C
• Appearance: /
• Density: 1.48 g/cm³
• Vapor Pressure: 1.38E-08mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(17228-98-7)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(17228-98-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 17228-98-7(Hazardous Substances Data)

Usage

General Description

2-(4-Chlorophenyl)-1,3-thiazole-4-carboxylic acid is a chemical compound with a molecular formula C11H7ClN2O2S. It is a thiazole derivative that contains a chlorophenyl group and a carboxylic acid functional group. 2-(4-CHLOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has shown potential biological activity, including antimicrobial and anticancer properties. The presence of the chlorophenyl and carboxylic acid groups makes it a valuable building block for the development of novel drugs and other bioactive compounds.

InChI:InChI=1/C10H6ClNO2S/c11-7-3-1-6(2-4-7)9-12-8(5-15-9)10(13)14/h1-5H,(H,13,14)/p-1

Upstream product

• 36093-99-9 [2-(4-chloro-phenyl)-thiazol-4-yl]-methanol 
• 61786-00-3 ethyl 2-(4-chlorophenyl)thiazole-4-carboxylate 
• 2521-24-6 4-chlorothiobenzamide 
• 40361-62-4 4-chloromethyl-2-(4-chloro-phenyl)-4,5-dihydro-thiazol-4-ol 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1113-59-3 bromopyruvic acid 
• 1315510-11-2 methyl 2-(4-chlorophenyl)thiazole-4-carboxylate 
• 86264-82-6 (4R)-methyl 2-(4-chlorophenyl)-1,3-thiazolidine-4-carboxylate 

Downstream Products

• 57677-82-4 1-[2-(4-chloro-phenyl)-thiazol-4-yl]-2-diazo-ethanone 
• 104106-86-7 2-(4-chlorophenyl)-4-thiazolecarboxylic acid chloride 
• 57677-86-8 2-chloro-1-[2-(4-chloro-phenyl)-thiazol-4-yl]-ethanone 
• 65823-92-9 1-[2-(4-chloro-phenyl)-thiazol-4-yl]-ethanone 

Relevant articles and documents

Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor

Fibroblast activation protein (FAP) belongs to the family of prolyl-specific serine proteases and displays both exopeptidase and endopeptidase activities. FAP expression is undetectable in most normal adult tissues, but is greatly upregulated in sites of tissue remodeling, which include fibrosis, inflammation and cancer. Due to its restricted expression pattern and dual enzymatic activities, FAP inhibition is investigated as a therapeutic option for several diseases. In the present study, we described the structure–activity relationship of several synthesized compounds against DPPIV and prolyl oligopeptidase (PREP). In particular, BR102910 (compound 24) showed nanomolar potency and high selectivity. Moreover, the in vivo FAP inhibition study of BR102910 (compound 24) using C57BL/6J mice demonstrated exceptional profiles and satisfactory FAP inhibition efficacy. Based on excellent in vitro and in vivo profiles, the potential of BR102910 (compound 24) as a lead candidate for the treatment of type 2 diabetes is considered.

Synthesis, Activity, and Docking Study of Novel Phenylthiazole-Carboxamido Acid Derivatives as FFA2 Agonists

Free fatty acid receptor 2 (FFA2), also known as GPR43, is activated by short-chain fatty acids (SCFAs) that are mainly produced by the gut microbiota through the fermentation of undigested carbohydrates and dietary fibers. FFA2 currently appears to be a

AMIDOPYRIDINE DERIVATIVE, AND USE THEREOF

The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.