36093-99-9

Basic information

• Product Name: [2-(4-CHLORO-PHENYL)-THIAZOL-4-YL]-METHANOL
• Synonyms: [2-(4-CHLORO-PHENYL)-THIAZOL-4-YL]-METHANOL;2-(4-Chlorophenyl)thiazole-4-methanol;[2-(4-chlorophenyl)-1,3-thiazol-4-yl]Methanol
• CAS NO: 36093-99-9
• Molecular Formula: C₁₀H₈ClNOS
• Molecular Weight: 225.69
• Mol File: 36093-99-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 396 °C at 760 mmHg
• Flash Point: 193.3 °C
• Appearance: /
• Density: 1.383 g/cm³
• CAS DataBase Reference: [2-(4-CHLORO-PHENYL)-THIAZOL-4-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-CHLORO-PHENYL)-THIAZOL-4-YL]-METHANOL(36093-99-9)
• EPA Substance Registry System: [2-(4-CHLORO-PHENYL)-THIAZOL-4-YL]-METHANOL(36093-99-9)

Safety Data

• Hazardous Substances Data: 36093-99-9(Hazardous Substances Data)

Usage

General Description

The chemical "[2-(4-chloro-phenyl)-thiazol-4-yl]-methanol" is a thiazole derivative with a methanol group attached. The molecule contains a thiazole ring with a 4-chloro-phenyl group attached at the 2-position. Thiazoles are heterocyclic compounds that contain a five-membered ring with sulfur and nitrogen atoms. The presence of the chloro-phenyl group and the methanol moiety make this compound potentially useful in pharmaceutical and chemical research, with potential applications in drug development and organic synthesis. The compound's chemical structure and properties make it an interesting target for further study and exploration in the field of medicinal chemistry and chemical synthesis.

Upstream product

• 40361-62-4 4-chloromethyl-2-(4-chloro-phenyl)-4,5-dihydro-thiazol-4-ol 
• 21278-77-3 2-(4-chlorophenyl)thiazole-4-carbaldehyde 
• 17969-22-1 4-chloromethyl-2-(4-chloro-phenyl)-thiazole 
• 2521-24-6 4-chlorothiobenzamide 
• 623-03-0 4-Cyanochlorobenzene 
• 61786-00-3 ethyl 2-(4-chlorophenyl)thiazole-4-carboxylate 

Downstream Products

• 52041-83-5 [5-bromo-2-(4-chloro-phenyl)-thiazol-4-yl]-methanol 
• 52041-97-1 5-bromo-2-(4-chloro-phenyl)-thiazole-4-carboxylic acid 
• 17228-98-7 2-(4-chlorophenyl)thiazole-4-carboxylic acid 
• 52041-93-7 5-bromo-2-(4-chloro-phenyl)-thiazole-4-carbaldehyde 
• 1163175-95-8 2-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methoxy}-4-[4-(2-hydroxyethoxy)phenyl]-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carbonitrile 
• 1244030-74-7 2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene 
• 17969-22-1 4-chloromethyl-2-(4-chloro-phenyl)-thiazole 
• 21278-78-4 1-((2-(4-chlorophenyl)thiazol-4-yl)methylene)thiosemicarbazide 

Relevant articles and documents

Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells

Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.

Synthesis and biological evaluation of new 2-aryl-4-((4-aryl-1H-1,2,3-triazol-1-yl)methyl)thiazole derivatives

A series of 2-aryl-4-((4-aryl-1H-1,2,3-triazol-1-yl)methyl)thiazole derivatives (8a–p) have been synthesized. The structure of the newly synthesized compounds was determined by spectral analysis. The title compounds were screened for their preliminary ant

Discovery of the disubstituted oxazole analogues as a novel class anti-tuberculotic agents against MDR- and XDR-MTB

A high-throughput screening effort on 45,000 compounds resulted in the discovery of a disubstituted oxazole as a new structural class inhibitor of Mycobacterium tuberculosis (Mtb). In order to improve the activity and investigate the SAR of this scaffold, a series of disubstituted azole analogues have been designed and synthesized. The newly synthesized compounds 1a-y were evaluated for their in vitro anti-TB activity versus replicating, multi- and extensive drug resistant Mtb strains. All the compounds, except 1o, 1p and 1q, showed potent anti-TB activity with MIC of 1-64 mg/L. The test of broad spectrum panel revealed that this series are specific to Mtb. The cytotoxicity assessment indicated that the compounds were not cytotoxic against HEK 293 cells. The compounds could have a novel mechanism to anti-Mtb as they can inhibit drug sensitive and drug resistant Mtb.