21278-77-3

Basic information

• Product Name: 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE
• Synonyms: 2-(4-CHLOROPHENYL)-1,3-THIAZOLE-4-CARBALDEHYDE;2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE
• CAS NO: 21278-77-3
• Molecular Formula: C₁₀H₆ClNOS
• Molecular Weight: 223.68
• Mol File: 21278-77-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 377.571 °C at 760 mmHg
• Flash Point: 182.149 °C
• Appearance: /
• Density: 1.388 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: 2-8°C
• PKA: -0.30±0.10(Predicted)
• CAS DataBase Reference: 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(21278-77-3)
• EPA Substance Registry System: 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE(21278-77-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 21278-77-3(Hazardous Substances Data)

Usage

General Description

2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde is a chemical compound with the molecular formula C10H6ClNO. It is a pale yellow to light brown powder with a molecular weight of 197.61 g/mol. 2-(4-CHLORO-PHENYL)-THIAZOLE-4-CARBALDEHYDE is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in the production of various organic compounds and has potential applications in research and development. Its chemical properties and structure make it suitable for use in a wide range of chemical reactions and processes.

InChI:InChI=1/C10H6ClNOS/c11-8-3-1-7(2-4-8)10-12-9(5-13)6-14-10/h1-6H

Upstream product

• 40361-62-4 4-chloromethyl-2-(4-chloro-phenyl)-4,5-dihydro-thiazol-4-ol 
• 2521-24-6 4-chlorothiobenzamide 
• 623-03-0 4-Cyanochlorobenzene 
• 61786-00-3 ethyl 2-(4-chlorophenyl)thiazole-4-carboxylate 
• 17969-22-1 4-chloromethyl-2-(4-chloro-phenyl)-thiazole 
• 20287-70-1 ethyl 2-(2-(4-chlorophenyl)thiazol-4-yl)acetate 

Downstream Products

• 36093-99-9 [2-(4-chloro-phenyl)-thiazol-4-yl]-methanol 
• 108735-90-6 2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde oxime 
• 17969-21-0 2-(4-chlorophenyl)thiazole-4-carbonitrile 
• 174006-80-5 2-(4-chlorophenyl)thiazole-4-carbothioamide 
• 52041-83-5 [5-bromo-2-(4-chloro-phenyl)-thiazol-4-yl]-methanol 
• 52041-93-7 5-bromo-2-(4-chloro-phenyl)-thiazole-4-carbaldehyde 
• 52041-97-1 5-bromo-2-(4-chloro-phenyl)-thiazole-4-carboxylic acid 
• 1187020-64-9 4-[2-(4-chlorophenylthiazol)-4-yl]-2,6-dimethyl-3,5-diacethyl-1,4-dihydropyridine 
• 1187020-68-3 4-[2-(4-chlorophenylthiazol)-4-yl]-2,6-dimethyl-3,5-dibenzoyl-1,4-dihydropyridine 
• 1244030-74-7 2-amino-3-cyano-4-[2-(4-chlorophenyl)thiazol-4-yl]-7-(dimethylamino)-4H-chromene 
• 1585214-70-5 rac-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate 
• 1585214-74-9 (R)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate 
• 1585214-86-3 (S)-2-(ethoxycarbonyl)-1-(2-(4-chlorophenyl)thiazol-4-yl)ethyl butanoate 
• 1585214-82-9 (R)-ethyl 3-(2-(4-chlorophenyl)thiazol-4-yl)-3-hydroxypropanoate 

Relevant articles and documents

Synthesis of new 2-(thiazol-4-yl)thiazolidin-4-one derivatives as potential anti-mycobacterial agents

To search for potent antimycobacterial lead compounds, a new series of 3-substituted phenyl-2-(2-(substituted phenyl)thiazol-4-yl) thiazolidin-4-one (5a-t) derivatives have been synthesized by the condensation of 2-substituted phenyl thiazole-4-carbaldehy

Synthesis, Characterization, and Antimicrobial Screening of 4″-methyl-2,2″-diaryl-4,2′:4′,5″-terthiazole Derivatives

A series of novel 4″-methyl-2,2″-diaryl-4,2′:4′,5″-terthiazole (8a-p) derivatives has been synthesized and screened for antibacterial activity against four pathogenic bacteria, Escherichia coli, Pseudomonas flurescence, Staphylococcus aureus, and Bacillus subtilis. Among them, compounds 8a and 8j exhibited excellent antibacterial activity with minimum inhibitory concentration range of 1.0 to 5.3?μg/mL and compounds 8m and 8p exhibited moderate to good antibacterial activity with minimum inhibitory concentration range of 16.9 to 29.7?μg/mL against all tested strains. All the synthesized compounds were screened for their in vitro antifungal activity against Cocinida candida. Most of the compounds reported moderate antifungal activity. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimicrobial agent.

Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives

The increase in antibiotic resistance due to multiple factors has warranted the need for search of new compounds which are active against multidrug resistant pathogens. In this context a small focused library of thiosemicarbazide derivatives of 2-arylthiazole-4-carbaldehyde, 4-methyl-2-arylthiazole-5-carbaldehyde and 1-(4-methyl-2-arylthiazol-5-yl) ethanone, (5a–l) has been synthesized. The title compounds were screened for inhibitory activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis Bacille Calmette Guerin (ATCC 35743) strains. The synthesized compounds, 5a–l were further assayed for their cytotoxic activity against the two human cancer cell lines, HeLa and human colon carcinoma 116 cell lines and showed no significant cytotoxic activity against these two cell lines at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antibacterial activity against Gram-negative bacteria, Escherichia coli, Pseudomonas flurescence and Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis. Most of the synthesized compounds showed moderate activity against fungal strain Candida albicans. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimycobacterial agent.