172823-12-0 Usage
Description
(R)-3-(N-tert-butoxycarbonylamine)-3-phenylpropanenitrile, with the molecular formula C17H22N2O2, is a chiral chemical compound featuring a non-superimposable mirror image. As a nitrile derivative of benzene, it possesses a phenyl group attached to the carbon atom and includes a tert-butoxycarbonylamine (Boc) group, which serves as a protective group in organic chemistry. (R)-3-(N-tert-butoxycarbonylamine)-3-phenylpropanenitrile plays a significant role in the development of pharmaceuticals and biologically active molecules due to its unique structural characteristics.
Uses
Used in Pharmaceutical Research:
(R)-3-(N-tert-butoxycarbonylamine)-3-phenylpropanenitrile is used as an intermediate in the synthesis of various pharmaceuticals for [application reason] its unique structural features that allow for the creation of biologically active molecules.
Used in Organic Synthesis:
In the field of organic chemistry, (R)-3-(N-tert-butoxycarbonylamine)-3-phenylpropanenitrile is used as a key building block for [application reason] its ability to be modified and functionalized to produce a wide range of compounds with potential applications in various industries.
Used in Chemical Protection:
The Boc group present in (R)-3-(N-tert-butoxycarbonylamine)-3-phenylpropanenitrile is used as a protective group in chemical reactions for [application reason] its ability to shield functional groups, preventing unwanted side reactions and ensuring the selective formation of desired products.
Used in Chiral Compounds Synthesis:
As a chiral compound, (R)-3-(N-tert-butoxycarbonylamine)-3-phenylpropanenitrile is used in the synthesis of enantiomerically pure compounds for [application reason] its non-superimposable mirror image, which is crucial for the development of drugs with specific biological activities and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 172823-12-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,8,2 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 172823-12:
(8*1)+(7*7)+(6*2)+(5*8)+(4*2)+(3*3)+(2*1)+(1*2)=130
130 % 10 = 0
So 172823-12-0 is a valid CAS Registry Number.
172823-12-0Relevant articles and documents
Direct catalytic enantioselective Mannich-type reaction of α,α-dithioacetonitriles with imines using chiral bis(imidazoline)-Pd complexes
Kondo, Masaru,Saito, Hikari,Nakamura, Shuichi
, p. 6776 - 6779 (2017)
The first highly enantioselective reaction of α,α-dithioacetonitriles with imines has been developed. Good yields and enantioselectivity were observed for the reaction of various imines using chiral bis(imidazoline) catalysts. The obtained products can be
Direct Catalytic Asymmetric Addition of Acetonitrile to Aldimines
Saito, Akira,Kumagai, Naoya,Shibasaki, Masakatsu
, p. 8187 - 8190 (2019/09/07)
Despite significant advances in catalytic asymmetric reactions with decent stereocontrol, those using acetonitrile as a pronucleophile are often disregarded due to their low reactivity and insufficient enantioselectivity. Herein we report the resurgence of this reaction in the chemical toolbox with high enantioselectivity (avg. > 95% ee). The combined use of a Ni(II) complex ligated with a chiral biscarbene and tBuOK engages acetonitrile in the catalytic generation of an α-cyanocarbanion and subsequent highly enantioselective addition to aldimines.
Catalytic enantioselective mannich-type reaction with β-phenyl sulfonyl acetonitrile
Gonzalez, Pedro B.,Lopez, Rosa,Palomo, Claudio
supporting information; experimental part, p. 3920 - 3922 (2010/08/06)
Figure presented The organocatalytic addition of β-phenyl sulfonyl acetonitrile 1 to either N-Boc-protected α-amido sulfones or imines allowed the synthesis of enantioenriched α-unsubstituted β-amino nitriles through a Mannich-type reaction.
