212560-65-1

Basic information

• Product Name: tert-butyl (2R)-2-aMino-4-oxo-2-phenylbutanoate
• Synonyms: tert-butyl (2R)-2-aMino-4-oxo-2-phenylbutanoate;(R)-tert-butyl 3-oxo-1-phenylpropylcarbaMate;(S)-benzyl 3-oxo-1-phenylpropylcarbaMate
• CAS NO: 212560-65-1
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.30556
• Mol File: 212560-65-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 371.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.075±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.56±0.46(Predicted)
• CAS DataBase Reference: tert-butyl (2R)-2-aMino-4-oxo-2-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2R)-2-aMino-4-oxo-2-phenylbutanoate(212560-65-1)
• EPA Substance Registry System: tert-butyl (2R)-2-aMino-4-oxo-2-phenylbutanoate(212560-65-1)

Safety Data

• Hazardous Substances Data: 212560-65-1(Hazardous Substances Data)

Upstream product

• 158807-51-3 (R)-3-tert-butoxycarbonylamino-3-phenylpropionic acid methyl ester 
• 34619-03-9 tert-butyldicarbonate 
• 143216-63-1 (2R,4R)-4-Amino-4-phenyl-butane-1,2-diol 
• 172823-12-0 (R)-3-(N-tert-butoxycarbonylamine)-3-phenylpropanenitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 117049-14-6 tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate 
• 2935-35-5 (S)-2-phenylglycine 
• 20989-17-7 (2S)-2-phenylglycinol 
• 110143-62-9 (S)-(+)-<2-<(methylsulfonyl)oxy>-1-phenylethyl>carbamic acid 1,1-dimethylethyl ester 
• 1100-88-5 benzyltriphenylphosphonium chloride 
• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 157732-87-1 (4S)-2,2-dimethyl-4-(2-phenylethyl)-1,3-dioxolane 
• 147976-19-0 (4S)-2,2-dimethyl-4-[(E)-2-phenylethenyl]-1,3-dioxolane 
• 620990-00-3 sulfamic acid 1-(tert-butyl-diphenyl-silanyloxymethyl)-3-phenyl-propyl ester 

Downstream Products

• 212560-67-3 (E)-(R)-5-tert-Butoxycarbonylamino-5-phenyl-pent-2-enoic acid ethyl ester 
• 3466-80-6 (R)-(+)-6-phenylpiperidine 
• 212560-70-8 (+)-(6R)-6-phenylpiperidin-2-one 
• 212560-69-5 (R)-5-Amino-5-phenyl-pentanoic acid ethyl ester 
• 212560-68-4 (R)-ethyl 5-[(tert-butoxycarbonyl)amino]-5-phenylpentanoate 
• 148700-85-0 L 733060 
• 159249-47-5 tert-butyl (2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylate 
• 191669-62-2 (S)-tert-butyl 3-carbonyl-2-phenylpiperidine-1-carboxylic acid 
• 562817-60-1 (2S,3S)-1-(tert-butyloxycarbonyl)-2-phenyl-3-[(3,5)-bis(trifluoromethyl)benzyloxy]piperidine 

Relevant articles and documents

A Concise Enantioselective Synthesis of (+)-L-733,060 and (+)-T-2328 via Sequential Proline Catalysis

A new, sequential proline-catalyzed approach to the synthesis of (+)-L-733,060 and (+)-T-2328 in high optical purity (93% ee) is described starting from phenyl N-Boc imine. The strategy involves proline-catalyzed Mannich reaction of an arylimine with acet

Controlling stereoselectivity in the aminocatalytic enantioselective mannich reaction of aldehydes with in situ generated N-carbamoyl imines

A simple and convenient method for the direct, aminocatalytic, and highly enantioselective Mannich reactions of aldehydes with in situ generated N-carbamoyl imines has been developed. Both α-imino esters and aromatic imines serve as suitable electrophilic components. Moreover, the judicious selection of commercially available secondary amine catalysts allows selective access to the desired stereoisomer of the N-tert-butoxycarbonyl (Boc) or N-carbobenzyloxy (Cbz) Mannich adducts, with high control over the syn or anti relative configura-tion and almost perfect enantioselectivity. Besides the possibility to fully control the stereochemistry of the Mannich reaction, the main advantage of this method lies in the operational simplicity; the highly reactive N-carbamate-protected imines are generated in situ from stable and easily handled aamido sulfones. 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Stereoselective synthesis of the 1,N2-deoxyguanosine adducts of cinnamaldehyde. A stereocontrolled route to deoxyguanosine adducts of α,β-unsaturated aldehydes

α,β-Unsaturated aldehydes (enals) react with deoxyguanosine and have mutagenic potential. For higher enals, the reaction of deoxyguanosine gives diastereomeric 6-substituted 8-hydroxypyrimidopurinone products. These stereoisomers may have different local