172875-52-4

Basic information

• Product Name: 1H-Imidazole-4-carboxylicacid,2-propyl-(9CI)
• Synonyms: 2-Propyl-1H-imidazole-4-carboxylic acid;1H-Imidazole-4-carboxylicacid,2-propyl-(9CI)
• CAS NO: 172875-52-4
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.168
• Product Categories: CARBOXYLICACID;GLYCINESCAFFOLD
• Mol File: 172875-52-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 436.0±18.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• PKA: 2.75±0.10(Predicted)
• CAS DataBase Reference: 1H-Imidazole-4-carboxylicacid,2-propyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4-carboxylicacid,2-propyl-(9CI)(172875-52-4)
• EPA Substance Registry System: 1H-Imidazole-4-carboxylicacid,2-propyl-(9CI)(172875-52-4)

Safety Data

• Hazardous Substances Data: 172875-52-4(Hazardous Substances Data)

Usage

Structure

A five-membered imidazole ring with two nitrogen atoms, a carboxylic acid group, and a propyl group attached to the ring.

Derivative of

Imidazole

Usage

In organic synthesis and medicinal chemistry as a building block for creating pharmaceuticals and bioactive compounds.

Potential applications

Development of drugs for various medical conditions and as a research tool in studying imidazole-containing compounds.

Upstream product

• 51802-42-7 2-propylimidazole-4,5-dicarbonitrile 
• 58954-23-7 2-propyl-1H-imidazole-4,5-dicarboxylic acid 

Downstream Products

• 172875-79-5 3-(2'-Carboxy-biphenyl-4-ylmethyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

Nonpeptide angiotensin II receptor antagonists: Synthesis, biological activities, and structure - Activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds

A series of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds were prepared and evaluated for their antagonistic activities to the angiotensin II (AII) receptor. Among them, the 4-(1-hydroxyalkyl)-imidazole derivatives had strong binding affinity to the AII receptor and potently inhibited the AII-induced pressor response by intravenous administration. Various esters of these acids showed potent and long-lasting antagonistic activity by oral administration. The most promising compounds were (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (CS-866) and (pivaloyloxy)-methyl esters of 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[(2′-1H-tetrazol-5-ylbiphenyl-4-yl) -methyl]imidazole-5-carboxylic acid (26c). A study involving stereochemical comparison of 26c with the acetylated C-terminal pentapeptide of AII was also undertaken.