58954-23-7Relevant articles and documents
Preparation method of diacid
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Paragraph 0006; 0032; 0034-0040; 0045-0050, (2021/05/12)
The invention relates to a preparation method of diacid, and belongs to the field of medicinal chemistry. The preparation method provided by the invention comprises: carrying out carboxylation reaction on raw materials under the action of acid under a continuous flow reaction condition. The method provided by the invention has the advantages of cheap and easily available raw materials, simple process, low cost, high product purity and yield, green and environment-friendly process, and facilitation of industrialization.
Influence of Oxidation Conditions on the Yield of 2-Substituted Imidazole-4,5-dicarboxylic Acids
Brusina,Gubina, Yu. A.,Nikolaev,Ramsh,Piotrovskii
, p. 874 - 878 (2018/07/06)
Conditions were found which allow 2-alkyl-substituted imidazole-4,5-dicarboxylic acids to be synthesized in preparative quantities by the oxidation of 2-alkylbenzimidazoles with hydrogen peroxide. It was shown that optimal results can be obtained at the concentration of 2-alkylimidazole in sulfuric acid of 1 M and the hydrogen peroxide: 2-alkylbenzimidazole molar ratio of 11: 1. Oxidation under these conditions results in higher yields of the target 2-alkylimidazole-4,5-dicarboxylic acids, including those with a branched alkyl group.
Olmesartan high purity intermediate 2-propyl imidazole -4,5-dicarboxylic acid preparation method and application
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Paragraph 0086-0089, (2017/02/28)
The invention provides a preparation method of 2-propylimidazolyl-4,5-dicarboxylic acid (1). According to the method, the concentration of the sulfuric acid solution, the volume/mass ratio of the sulfuric acid solution to 2-propyl benzimidazole, the volume ratio of the oxydol to the sulfuric acid water solution, reaction time, added water volume and cooling recrystallization temperature are accurately controlled to obviously lower the content of the impurity imidazolyl-4,5-dicarboxylic acid (8), thereby further obtaining the high-purity olmesartan medoxomil. The invention also provides a compound disclosed as Formula 9 and application thereof in olmesartan medoxomil preparation as a control quality standard substance.